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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Related Experiment Video

Updated: Mar 1, 2026

Experimental Glaucoma Induced by Ocular Injection of Magnetic Microspheres
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Sumatriptan-induced angle-closure glaucoma: A case report.

Cherng-Ru Hsu1, Yi-Hao Chen, Ming-Cheng Tai

  • 1Department of Ophthalmology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.

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|June 1, 2017
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Summary
This summary is machine-generated.

Sumatriptan can rarely cause bilateral angle-closure glaucoma, an ophthalmic emergency. Prompt treatment with cycloplegics, steroids, and aqueous suppressants is crucial for vision recovery.

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Area of Science:

  • Ophthalmology
  • Pharmacology

Background:

  • Drug-induced bilateral angle-closure glaucoma is a rare but serious condition.
  • Prompt diagnosis and treatment are vital to prevent permanent vision loss.

Observation:

  • A young woman with migraine developed bilateral angle-closure glaucoma after sumatriptan use.
  • The patient presented with acute elevated intraocular pressure and myopic shift.

Findings:

  • Topical phenylephrine initially lowered intraocular pressure, suggesting a possible link to malignant glaucoma.
  • Symptoms resolved rapidly with a combination of topical cycloplegic agents, steroids, and aqueous suppressants.

Implications:

  • This case highlights the potential for sumatriptan to induce angle-closure glaucoma, possibly via a mechanism related to malignant glaucoma.
  • Early recognition and appropriate management are essential for favorable outcomes in this rare ophthalmic emergency.