Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

2.0K
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
2.0K
What is the Immune System?01:38

What is the Immune System?

137.8K
Overview
137.8K
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

85.2K
Overview
85.2K
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

5.9K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
5.9K
Immunodeficiency Diseases01:25

Immunodeficiency Diseases

2.7K
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
2.7K
T Cell Types and Functions01:24

T Cell Types and Functions

2.9K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
2.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Synergistic bactericidal and anticancer potential of rubidium and silver-containing phosphate-based bioglasses.

Scientific reports·2025
Same author

Exploring the structural landscape of universal stress proteins in Archaea.

World journal of microbiology & biotechnology·2025
Same author

Cardiovascular risk and cardiac involvement in idiopathic inflammatory myopathies: insights from a cross-sectional Swedish single-centre study.

Scandinavian journal of rheumatology·2025
Same author

Osteopenia/osteoporosis develops in the early phase of disease in patients with idiopathic inflammatory myopathies.

Scandinavian journal of rheumatology·2021
Same author

A THz transparent 3D printed microfluidic cell for small angle x-ray scattering.

The Review of scientific instruments·2020
Same author

In cellulo crystallization of Trypanosoma brucei IMP dehydrogenase enables the identification of genuine co-factors.

Nature communications·2020

Related Experiment Video

Updated: Mar 1, 2026

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry
12:36

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry

Published on: June 26, 2018

10.0K

Survivin in autoimmune diseases.

G Gravina1, C Wasén1, M J Garcia-Bonete2

  • 1Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Autoimmunity Reviews
|June 1, 2017
PubMed
Summary

Survivin, a protein crucial for cell division and immune homeostasis, plays a key role in autoimmune diseases by promoting inflammation and autoantibody production. Inhibiting survivin shows promise for treating both cancers and autoimmune conditions.

Keywords:
AutoimmunityHypoxiaInflammationSmokingSurvivinTherapy

More Related Videos

Bioluminescent Monitoring of Graft Survival in an Adoptive Transfer Model of Autoimmune Diabetes in Mice
10:03

Bioluminescent Monitoring of Graft Survival in an Adoptive Transfer Model of Autoimmune Diabetes in Mice

Published on: November 18, 2022

2.3K
Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity
11:12

Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity

Published on: April 11, 2019

7.5K

Related Experiment Videos

Last Updated: Mar 1, 2026

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry
12:36

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry

Published on: June 26, 2018

10.0K
Bioluminescent Monitoring of Graft Survival in an Adoptive Transfer Model of Autoimmune Diabetes in Mice
10:03

Bioluminescent Monitoring of Graft Survival in an Adoptive Transfer Model of Autoimmune Diabetes in Mice

Published on: November 18, 2022

2.3K
Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity
11:12

Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity

Published on: April 11, 2019

7.5K

Area of Science:

  • Immunology
  • Cell Biology
  • Molecular Pathology

Background:

  • Survivin is vital for cell division, apoptosis, and immune homeostasis.
  • It regulates T-cell differentiation, memory maintenance, and B-cell maturation.
  • Survivin is an established marker of malignant transformation.

Purpose of the Study:

  • To review the non-malignant functions of survivin.
  • To focus on survivin's role in the pathogenesis of autoimmune diseases.
  • To highlight survivin's clinical utility and therapeutic inhibition strategies.

Main Methods:

  • Literature review of survivin's functions in non-malignant and autoimmune conditions.
  • Analysis of survivin's involvement in immune cell regulation and autoantibody production.
  • Examination of survivin's diagnostic and prognostic value in various autoimmune diseases.

Main Results:

  • Survivin enhances antigen presentation and autoreactive cell persistence during inflammation.
  • It is implicated in rheumatoid arthritis, psoriasis, multiple sclerosis, and other autoimmune disorders.
  • Survivin levels serve as diagnostic and prognostic markers in these conditions.

Conclusions:

  • Survivin is a critical mediator in the pathology of autoimmune diseases.
  • Targeting survivin offers a potential therapeutic strategy for autoimmune disorders.
  • Further research into survivin inhibition is warranted for clinical applications in autoimmune diseases and cancer.