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Human lymphoblastoid interferon does not increase survival when added to mitozantrone in the treatment of
M G Brook1, A A Dunk, J A McDonald
1Academic Department of Medicine, Royal Free Hospital and Medical School, London, UK.
Alimentary Pharmacology & Therapeutics
|August 1, 1987
Abstract:
Human lymphoblastoid interferon, in an initial dose of 2.5 MU m-2 weekly i.m., was given with mitozantrone 12 mg m-2 i.v. every 3 weeks to 15 patients with hepatocellular carcinoma. The survival curve for these patients was worse than that of 15 patients previously treated with mitozantrone alone; there were more long-term survivors in those not given interferon; more side-effects were seen in the group given interferon. The addition of interferon to mitozantrone in the management of hepatocellular carcinoma is not recommended.