Aceclofenac oil drops: characterization and evaluation against ocular inflammation

Area of Science:

• Ophthalmology
• Pharmaceutics
• Drug Delivery

Background:

• Ocular inflammatory diseases like uveitis and dry eye syndrome are often managed with eye drops.
• Current treatments may have limitations in efficacy or delivery.

Purpose of the Study:

• To formulate and evaluate aceclofenac oil-based eye drops for ocular delivery.
• To assess the transcorneal permeation and anti-inflammatory potential of these novel formulations.

Main Methods:

• Aceclofenac ophthalmic solutions were prepared using various vegetable oils, with and without benzyl alcohol.
• Transcorneal permeation studies were conducted using animal corneas (goat, sheep, buffalo).
• Anti-inflammatory effects were evaluated in rabbit eyes using an arachidonic acid-induced inflammation model.

Main Results:

• An aceclofenac ophthalmic solution in linseed oil with benzyl alcohol showed the highest corneal permeation.
• Partition characteristics of aceclofenac in linseed oil supported permeation findings.
• The optimized linseed oil formulation exhibited significant inhibition of ocular inflammation (p < .05).

Conclusions:

• Aceclofenac oil formulations, particularly in linseed oil with benzyl alcohol, are effective for transcorneal delivery.
• This formulation demonstrates significant anti-inflammatory activity, suggesting potential for treating ocular inflammatory conditions.