Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Toxicity Testing in Animals01:23

Toxicity Testing in Animals

70
Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...
70
Bioactivation and Tissue Toxicity01:25

Bioactivation and Tissue Toxicity

69
Bioactivation is a metabolic process that transforms less reactive substances into highly reactive metabolites, initiating tissue toxicity. This transformation can lead to various toxic effects, including carcinogenesis and teratogenesis. Reactive metabolites are classified into two main types: electrophiles and free radicals.Electrophiles are electron-deficient species and are produced primarily by the enzyme cytochrome P-450 during the metabolism of compounds containing carbon, nitrogen, or...
69
Local Anesthetics: Adverse Effects01:12

Local Anesthetics: Adverse Effects

906
While local anesthetics are generally safe and well-tolerated, they can occasionally cause adverse effects that vary in severity. Local anesthetics can induce toxicity at two distinct levels. They can either produce local effects through direct contact with the neural elements or be absorbed into the bloodstream from the injection site, leading to systemic effects.
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
906

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Toxicological impact of Thiamethoxam on adult male rats: Histopathological, biochemical, and oxidative DNA damage assessment.

Toxicology reports·2025
Same author

Toxicity and postwithdrawal effects of ketamine on the reproductive function of male albino rats: Hormonal, histological, and immunohistochemical study.

Human & experimental toxicology·2020
Same author

Auto-brewery syndrome: Ethanol pseudo-toxicity in diabetic and hepatic patients.

Human & experimental toxicology·2016
See all related articles

Related Experiment Video

Updated: Mar 1, 2026

Author Spotlight: Advanced Integrated Model for Sepsis-Induced Myopathy and Single-Cell Metabolic Analysis
04:01

Author Spotlight: Advanced Integrated Model for Sepsis-Induced Myopathy and Single-Cell Metabolic Analysis

Published on: June 14, 2024

1.6K

Baclofen systemic toxicity: Experimental histopathological and biochemical study.

S Y Issa1, E M Hafez2, A S El-Banna1

  • 11 Faculty of Medicine, Department of Forensic Medicine and Clinical Toxicology, Alexandria University, Alexandria, Egypt.

Human & Experimental Toxicology
|June 2, 2017
PubMed
Summary

Baclofen exposure causes significant biochemical and histopathological damage in rat organs, including the liver, kidneys, and brain. This highlights baclofen toxicity as a critical medical emergency requiring prompt recognition and intervention.

Keywords:
Baclofenbiochemicalbraingastrichepatichistopathologylungrenaltoxicity

More Related Videos

A Multimodal Imaging Approach Based on Micro-CT and Fluorescence Molecular Tomography for Longitudinal Assessment of Bleomycin-Induced Lung Fibrosis in Mice
07:38

A Multimodal Imaging Approach Based on Micro-CT and Fluorescence Molecular Tomography for Longitudinal Assessment of Bleomycin-Induced Lung Fibrosis in Mice

Published on: April 13, 2018

12.2K
Back Mechanical Sensitivity Assessment in the Rat for Mechanistic Investigation of Chronic Back Pain
05:10

Back Mechanical Sensitivity Assessment in the Rat for Mechanistic Investigation of Chronic Back Pain

Published on: August 30, 2022

3.5K

Related Experiment Videos

Last Updated: Mar 1, 2026

Author Spotlight: Advanced Integrated Model for Sepsis-Induced Myopathy and Single-Cell Metabolic Analysis
04:01

Author Spotlight: Advanced Integrated Model for Sepsis-Induced Myopathy and Single-Cell Metabolic Analysis

Published on: June 14, 2024

1.6K
A Multimodal Imaging Approach Based on Micro-CT and Fluorescence Molecular Tomography for Longitudinal Assessment of Bleomycin-Induced Lung Fibrosis in Mice
07:38

A Multimodal Imaging Approach Based on Micro-CT and Fluorescence Molecular Tomography for Longitudinal Assessment of Bleomycin-Induced Lung Fibrosis in Mice

Published on: April 13, 2018

12.2K
Back Mechanical Sensitivity Assessment in the Rat for Mechanistic Investigation of Chronic Back Pain
05:10

Back Mechanical Sensitivity Assessment in the Rat for Mechanistic Investigation of Chronic Back Pain

Published on: August 30, 2022

3.5K

Area of Science:

  • Toxicology
  • Pharmacology
  • Pathology

Background:

  • Baclofen is a muscle relaxant with potential toxic effects.
  • Understanding baclofen's impact on organ systems is crucial for patient safety.

Purpose of the Study:

  • To investigate the biochemical and histopathological toxicity of baclofen in rat liver, gastric, lung, kidney, and brain tissues.
  • To evaluate acute and sub-chronic toxicity of baclofen.

Main Methods:

  • Thirty male albino rats were divided into control and experimental groups.
  • Experimental groups received either a single lethal dose (LD50) or gradually increasing doses of baclofen over one month.
  • Biochemical markers and histopathology of multiple organs were assessed.

Main Results:

  • Baclofen treatment significantly elevated liver enzymes, creatinine kinase, and prothrombin time.
  • Histopathological examination revealed dose-dependent tissue damage in the brain, lungs, stomach, liver, and kidneys.
  • Acute and sub-chronic baclofen exposure induced significant organ toxicity.

Conclusions:

  • Baclofen toxicity can lead to severe hepatorenal dysfunction and neurological symptoms.
  • Clinicians should consider baclofen toxicity in patients presenting with these signs.
  • Prompt diagnosis and management of baclofen toxicity are essential.