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Age-Related Autonomous Aldosteronism.

Kazutaka Nanba1, Anand Vaidya1, Gordon H Williams1

  • 1From Departments of Molecular and Integrative Physiology & Internal Medicine, University of Michigan, Ann Arbor (K.N., I.Z., W.E.R.); Center for Adrenal Disorders, Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (A.V., G.H.W.); and Division of Metabolism, Endocrinology, and Diabetes, University of Michigan, Ann Arbor (T.E., W.E.R.).

Circulation
|June 2, 2017
PubMed
Summary
This summary is machine-generated.

Aging impacts aldosterone production, increasing cardiovascular disease risk. Older individuals show reduced normal CYP11B2 expression but more aldosterone-producing cell clusters, suggesting autonomous aldosteronism.

Keywords:
agingaldosteronealdosterone-producing cell clustercytochrome P-450 CYP11B2primary aldosteronismrenin

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Area of Science:

  • Endocrinology
  • Cardiovascular Disease Research
  • Aging Biology

Background:

  • Aging and inappropriate aldosterone secretion are cardiovascular disease risk factors.
  • The specific effects of aging on aldosterone secretion and physiology remain unclear.

Purpose of the Study:

  • To investigate the relationship between aging and aldosterone synthase (CYP11B2) expression in adrenal glands.
  • To assess the association between age and renin-angiotensin-aldosterone system (RAAS) physiology in humans.

Main Methods:

  • Examined CYP11B2 expression and aldosterone-producing cell clusters in 127 human adrenal glands (age 9 months to 68 years) using immunohistochemistry.
  • Analyzed RAAS physiology in 677 participants (age 18-71 years) under high and restricted sodium diets using multivariable linear regression.

Main Results:

  • Adrenal CYP11B2 expression decreased with age, while aldosterone-producing cell clusters increased.
  • Older age was linked to a higher aldosterone-to-renin ratio on high sodium diets.
  • Aldosterone response to sodium restriction was blunted in older individuals.

Conclusions:

  • Aging is associated with reduced normal CYP11B2 expression and increased aldosterone-producing cell clusters in the adrenal gland.
  • This pattern suggests age-related autonomous aldosteronism and altered aldosterone physiology.
  • These findings may explain increased cardiovascular risk in aging populations.