Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

4.6K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.6K
Negative Regulator Molecules01:23

Negative Regulator Molecules

38.7K
Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
38.7K
Replicative Cell Senescence02:15

Replicative Cell Senescence

4.5K
Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds...
4.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Protocol for assessing enzymatic and non-enzymatic hydrogen sulfide production and levels.

STAR protocols·2026
Same author

Hydrogen sulfide at the intersection of aging and type 2 diabetes: Mechanisms of metabolic rewiring.

Ageing research reviews·2026
Same author

FGF21 connects ER stress to sulfide signaling to enhance cellular resilience.

Cell metabolism·2026
Same author

Enhanced non-enzymatic H<sub>2</sub>S generation extends lifespan and healthspan in male mice.

Cell metabolism·2025
Same author

Targeting macro- and micro-nutrient regulation of H<sub>2</sub>S signaling for the aging brain.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics·2025
Same author

Diet-Modifiable Redox Alterations in Ageing and Cancer.

Sub-cellular biochemistry·2024

Related Experiment Video

Updated: Mar 1, 2026

The Replica Set Method: A High-throughput Approach to Quantitatively Measure Caenorhabditis elegans Lifespan
11:58

The Replica Set Method: A High-throughput Approach to Quantitatively Measure Caenorhabditis elegans Lifespan

Published on: June 29, 2018

10.2K

Rapamycin keeps the reproductive clock ticking.

Christopher Hine1

  • 1Department of Cellular and Molecular Medicine, Cleveland Clinic Lerner Research Institute, Cleveland, OH 44195, USA.

Science Translational Medicine
|June 2, 2017
PubMed
Summary

Two weeks of rapamycin treatment improved ovarian function and reproductive lifespan in both young and old female mice. This suggests rapamycin may extend reproductive health and longevity.

Area of Science:

  • Gerontology
  • Reproductive Biology
  • Pharmacology

Background:

  • Aging is associated with declining ovarian function and reduced reproductive capacity.
  • Rapamycin, an mTOR inhibitor, has shown potential in extending lifespan and healthspan in various model organisms.
  • The effects of rapamycin on reproductive aging, particularly ovarian function, require further investigation.

Purpose of the Study:

  • To investigate the long-term effects of short-term rapamycin administration on ovarian function and reproductive longevity in female mice.
  • To determine if rapamycin treatment can mitigate age-related decline in reproductive parameters.

Main Methods:

  • Young and old female mice received daily oral administration of rapamycin for two weeks.
  • Ovarian function was assessed through various endpoints, including follicle counts and hormone levels.

More Related Videos

Use of Time-Lapse Microscopy and Stage-Specific Nuclear Depletion of Proteins to Study Meiosis in S. cerevisiae
07:48

Use of Time-Lapse Microscopy and Stage-Specific Nuclear Depletion of Proteins to Study Meiosis in S. cerevisiae

Published on: October 11, 2022

2.3K
Manipulation of Rhythmic Food Intake in Mice Using a Custom-Made Feeding System
07:34

Manipulation of Rhythmic Food Intake in Mice Using a Custom-Made Feeding System

Published on: December 16, 2022

3.0K

Related Experiment Videos

Last Updated: Mar 1, 2026

The Replica Set Method: A High-throughput Approach to Quantitatively Measure Caenorhabditis elegans Lifespan
11:58

The Replica Set Method: A High-throughput Approach to Quantitatively Measure Caenorhabditis elegans Lifespan

Published on: June 29, 2018

10.2K
Use of Time-Lapse Microscopy and Stage-Specific Nuclear Depletion of Proteins to Study Meiosis in S. cerevisiae
07:48

Use of Time-Lapse Microscopy and Stage-Specific Nuclear Depletion of Proteins to Study Meiosis in S. cerevisiae

Published on: October 11, 2022

2.3K
Manipulation of Rhythmic Food Intake in Mice Using a Custom-Made Feeding System
07:34

Manipulation of Rhythmic Food Intake in Mice Using a Custom-Made Feeding System

Published on: December 16, 2022

3.0K
  • Reproductive longevity was evaluated by tracking the duration of reproductive capacity.

    • Main Results:

    • Rapamycin treatment resulted in sustained improvements in ovarian function in both young and old mice.
    • A significant extension of reproductive lifespan was observed in the rapamycin-treated groups compared to controls.
    • No significant adverse effects were noted during the treatment period.

    Conclusions:

    • Short-term rapamycin administration can induce long-term beneficial effects on ovarian function and reproductive longevity.
    • Rapamycin represents a potential therapeutic strategy for enhancing reproductive healthspan and mitigating age-related fertility decline.
    • Further research is warranted to explore the underlying mechanisms and clinical applicability of rapamycin in human reproductive aging.