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Eccrine Squamous Syringometaplasia Associated with Pelubiprofen Therapy
Joon Won Huh1, Mingyul Jo1, Jisook Yoo1
1Department of Dermatology, Veterans Health Service Medical Center, Seoul, Korea.
Annals of Dermatology
|June 2, 2017
Summary
Eccrine squamous syringometaplasia (ESS) is a rare skin reaction. This case highlights a potential link between pelubiprofen, a non-steroidal anti-inflammatory drug (NSAID), and ESS development.
Area of Science:
- Dermatology
- Pharmacology
Background:
- Eccrine squamous syringometaplasia (ESS) is a distinctive skin eruption, often linked to chemotherapy.
- The etiology of ESS is not fully understood, with few reported associations with non-steroidal anti-inflammatory drugs (NSAIDs).
Observation:
- A rare case of ESS is presented in a patient treated with pelubiprofen, a novel NSAID.
- The skin eruption exhibited characteristic features of ESS and appeared during pelubiprofen therapy.
Findings:
- The patient developed ESS following the initiation of pelubiprofen treatment.
- Discontinuation of pelubiprofen led to the spontaneous resolution of the ESS.
Implications:
- This case suggests a potential association between pelubiprofen and the development of ESS.
- Further investigation into NSAID-induced ESS is warranted to understand its pathogenesis and clinical features.
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