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Current Perspective in the Discovery of Anti-aging Agents from Natural Products

Ai-Jun Ding1,2, Shan-Qing Zheng1,2, Xiao-Bing Huang1,2

  • 1State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, Yunnan, China.

Natural Products and Bioprospecting
|June 2, 2017
PubMed

Insights

Natural compounds can slow aging and extend lifespan by targeting conserved aging pathways. These findings offer promise for developing natural anti-aging medicines to combat age-related diseases.

Area of Science:

  • Gerontology and Longevity Research
  • Natural Product Chemistry
  • Molecular Biology of Aging

Background:

  • Aging is a complex process involving accumulated cellular damage, leading to organismal decline and death.
  • Understanding conserved aging pathways across species like Caenorhabditis elegans, fruit flies, and mice is crucial for developing human anti-aging therapies.
  • Natural products offer a promising avenue for anti-aging interventions due to their potential for fewer side effects and unique resource advantages.

Purpose of the Study:

  • To review natural products and extracts that demonstrate anti-aging effects.
  • To elucidate the mechanisms by which these natural compounds increase longevity in model organisms.
  • To explore the potential of natural products in the development of future anti-aging medicines.

Main Methods:

  • Literature review of studies on natural products and aging in model organisms.
  • Analysis of reported mechanisms of action for longevity-extending compounds.
  • Comparative analysis of conserved aging pathways in different species.

Main Results:

  • Numerous natural compounds and extracts have been identified that slow aging and extend lifespan in model organisms.
  • These natural products act through various conserved aging pathways.
  • Evidence suggests a significant potential for natural product-derived interventions in human aging.

Conclusions:

  • Natural products represent a valuable resource for discovering anti-aging compounds.
  • Targeting conserved aging pathways with natural products may lead to effective therapies for age-related diseases.
  • Further research into natural product mechanisms holds promise for developing novel anti-aging medicine.
Keywords:
AgingAnti-agingDrug screeningNatural products

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