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Neurodevelopmental outcome of isolated ventriculomegaly: a prospective cohort study

Omer Bar-Yosef1,2, Eran Barzilay2,3, Sara Dorembus2

  • 1Pediatric Neurology Unit, Sheba Medical Center, Ramat-Gan, Israel.

Prenatal Diagnosis
|June 2, 2017
PubMed

Insights

Children diagnosed with isolated ventriculomegaly (IVM) in utero typically have normal neurodevelopmental outcomes. The severity or asymmetry of IVM does not significantly impact these outcomes, offering reassurance for parents.

Area of Science:

  • Neuroscience
  • Developmental Pediatrics
  • Radiology

Background:

  • Isolated ventriculomegaly (IVM) is a prenatal finding with limited outcome data, primarily from ultrasound studies.
  • Magnetic resonance imaging (MRI) offers more detailed assessment of fetal brain development.

Purpose of the Study:

  • To evaluate the neurodevelopmental outcomes of children with isolated ventriculomegaly (IVM) using a large-scale, MRI-based study.
  • To determine if the severity or asymmetry of IVM affects neurodevelopmental outcomes.

Main Methods:

  • A cohort of 133 children with fetal brain MRI-confirmed isolated ventriculomegaly (IVM) was studied.
  • Neurodevelopmental assessment was performed using the Vineland Adaptive Behavior Scales (VABS) between 18 and 36 months of age.

Main Results:

  • The majority of children with isolated ventriculomegaly (IVM) demonstrated normal Vineland Adaptive Behavior Scales (VABS) scores.
  • No significant differences in VABS scores were observed between symmetric and asymmetric IVM, or between mild and moderate IVM.
  • Only 3.8% of children had abnormal VABS scores, with no significant difference based on IVM severity.

Conclusions:

  • A normal neurodevelopmental outcome is expected in isolated ventriculomegaly (IVM) cases.
  • The neurodevelopmental prognosis in IVM is not significantly affected by its severity or asymmetry.
  • Reassuring counseling is appropriate for parents following a thorough workup of isolated ventriculomegaly.
Abstract

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