Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Some observations on the immunological status in scleroderma (progressive systemic sclerosis).

A J Barnett, M N Cauchi, C S Hosking

    Australian and New Zealand Journal of Medicine
    |December 1, 1978
    PubMed
    Summary

    This study investigated immune status in scleroderma (progressive systemic sclerosis) patients. While some immune abnormalities were common, no consistent defects were found across all tests, suggesting potential subtle immune involvement.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The action of noradrenaline in man and its relation to pheochromocytoma and hypertension.

    Clinical science·2014
    Same author

    Reattachment of the proximal hamstring origin: outcome in patients with partial and complete tears.

    Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA·2014
    Same author

    Persistent pollen exposure during infancy is associated with increased risk of subsequent childhood asthma and hayfever.

    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2013
    Same author

    Medial patellofemoral ligament reconstruction: a prospective outcome assessment of a large single centre series.

    The Journal of bone and joint surgery. British volume·2012
    Same author

    Pets at birth do not increase allergic disease in at-risk children.

    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2012
    Same author

    Clinical and radiological results of the collarless polished tapered stem at 15 years follow-up.

    The Journal of bone and joint surgery. British volume·2012

    Area of Science:

    • Immunology
    • Rheumatology
    • Autoimmune Diseases

    Background:

    • Scleroderma, or progressive systemic sclerosis, is an autoimmune disease characterized by fibrosis and vascular abnormalities.
    • The role of immune system dysregulation in scleroderma pathogenesis remains incompletely understood.

    Purpose of the Study:

    • To comprehensively assess the immune status of patients with scleroderma.
    • To identify potential immune abnormalities associated with the disease.

    Main Methods:

    • Immunofluorescent techniques for autoantibody detection.
    • Complement component (C3, C4) levels assessment.
    • Immunoglobulin M (IgM) quantification.
    • Leukocyte iodination test for phagocytic function.
    • B cell and T cell enumeration.

    Related Experiment Videos

  • Mitogen reactivity assays.
  • Cutaneous delayed-type hypersensitivity skin tests.

    • Main Results:

    • Autoantibodies detected in 11/35 patients; elevated IgM in 24/34.
    • Normal complement levels (C3, C4) and B/T cell numbers in tested patients.
    • Phagocytic deficiency in 4/10 patients; impaired mitogen response in 2/10.
    • Most patients (22/23) exhibited normal skin reactivity.

    Conclusions:

    • Scleroderma patients exhibit common, yet inconsistent, immune abnormalities.
    • Standard immunological tests do not reveal a consistent immune defect in scleroderma.
    • Subtle or specific immune dysfunctions not detected by these assays may still contribute to disease manifestations.