Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

"Delayed return phenomenon" in amyotrophic lateral sclerosis.

S Ono1, Y Toyokura, T Mannen

  • 1Department of Neurology, Faculty of Medicine, University of Tokyo, Japan.

Acta Neurologica Scandinavica
|February 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Usefulness of 99mTc-ECD SPECT in diseases of the central nerve system: special reference to a comparison with 123I-IMP and 99mTc-HM-PAO SPECT].

Kaku igaku. The Japanese journal of nuclear medicine·1992
Same author

Confirmation of dialysate leakage by intraperitoneal administration of radioactive colloid.

Radiation medicine·1992
Same author

[Surgery for the patients whose total pulmonary vascular resistance was over 700 dyne during unilateral pulmonary artery occlusion test].

[Zasshi] [Journal]. Nihon Kyobu Geka Gakkai·1992
Same author

Accumulation of 99mTc-HM-PAO in photon deficient areas in bone scan of bone metastasis from hepatocellular carcinoma.

Annals of nuclear medicine·1992
Same author

Glutamate and aspartate are decreased in the skin in amyotrophic lateral sclerosis.

Acta neurologica Scandinavica·1992
Same author

Myocardial oxidative metabolism in normal subjects in fasting, glucose loading and dobutamine infusion states.

Annals of nuclear medicine·1992

Patients with amyotrophic lateral sclerosis (ALS) exhibit a "delayed return phenomenon" (DRP) in their skin elasticity. Microscopic analysis reveals unique changes in collagen structure and extracellular matrix in ALS patients with DRP.

Area of Science:

  • Dermatology
  • Neurology
  • Biochemistry

Background:

  • Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease.
  • Skin elasticity changes, termed the "delayed return phenomenon" (DRP), are observed in ALS patients.

Purpose of the Study:

  • To investigate the histological and ultrastructural characteristics of the reticular dermis in ALS patients with DRP.
  • To determine if DRP is a specific, previously unreported feature of ALS.

Main Methods:

  • Light microscopy of reticular dermis in ALS patients with DRP and controls.
  • Electron microscopy of reticular dermis in ALS patients with DRP.
  • Ruthenium red staining to identify amorphous material.

Main Results:

Related Experiment Videos

  • ALS patients with DRP showed reduced, loosely woven collagen bundles with wide inter-bundle spaces.
  • Controls with DRP had decreased dermal thickness but normal collagen bundles.
  • Electron microscopy revealed abundant amorphous material between collagen fibrils and bundles in ALS patients with DRP.

Conclusions:

  • The delayed return phenomenon (DRP) in ALS is associated with specific alterations in dermal collagen and extracellular matrix.
  • These findings suggest DRP is a novel histological marker potentially specific to amyotrophic lateral sclerosis.