Related Experiment Video
Updated: Mar 1, 2026

Rating L-DOPA-Induced Dyskinesias in the Unilaterally 6-OHDA-Lesioned Rat Model of Parkinson's Disease
Published on: October 4, 2021
Differential item functioning in the Unified Dyskinesia Rating Scale (UDysRS)
Sheng Luo1, Yuanyuan Liu1, Jeanne A Teresi2,3
1Department of Biostatistics, University of Texas Health Science Center, School of Public Health, Houston, Texas, USA.
Objective:
Test if differential item functioning due to gender, age, race/ethnicity, or education impacts Unified Dyskinesia Rating Scale scores.
Background:
Testing rating scales for differential item functioning is a core validation step. If differential item functioning exists, interpretation of item scores must consider secondary influences on dyskinesia ratings.
Methods:
Using Unified Dyskinesia Rating Scale translation databases (N = 3,132), we tested uniform and nonuniform differential item functioning. We required confirmation by two independent methods and considered differential item functioning pertinent if McFadden pseudo R2 magnitude statistics exceeded negligible ratings.
Results:
No age, race/ethnicity, or education nonuniform differential item functioning was identified. Gender nonuniform differential item functioning occurred for 2 items, both with negligible magnitude. Gender, race, and education uniform differential item functioning was observed for multiple items, all with negligible magnitude.
Conclusions:
The Unified Dyskinesia Rating Scale items effectively capture dyskinesia severity without pertinent gender, age, race/ ethnicity, or education influence. © 2017 International Parkinson and Movement Disorder Society.
More Related Videos
10:41Implantation of Osmotic Pumps and Induction of Stress to Establish a Symptomatic, Pharmacological Mouse Model for DYT/PARK-ATP1A3 Dystonia
Published on: September 12, 2020
05:51Induction and Assessment of Levodopa-induced Dyskinesias in a Rat Model of Parkinson's Disease
Published on: October 14, 2021