HDL cholesterol efflux capacity in rheumatoid arthritis patients: contributing factors and relationship with

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Beatriz Tejera-Segura1, María Macía-Díaz1, José David Machado2

  • 1Division of Rheumatology, Hospital Universitario de Canarias, 38320, Santa Cruz de Tenerife, Spain.

Arthritis Research & Therapy
|June 2, 2017
PubMed

Insights

Cholesterol efflux capacity (CEC) is linked to carotid plaque in rheumatoid arthritis (RA) patients. Higher CEC was associated with a reduced risk of carotid plaque, indicating its potential role in cardiovascular health for RA individuals.

Area of Science:

  • Cardiovascular Research
  • Rheumatology
  • Lipid Metabolism

Background:

  • Rheumatoid arthritis (RA) is associated with altered lipid profiles and inflammation.
  • Cholesterol efflux capacity (CEC), crucial for HDL function, is often impaired in RA patients.
  • CEC's link to cardiovascular disease in the general population suggests potential relevance in RA.

Purpose of the Study:

  • To investigate the relationship between CEC and subclinical carotid atherosclerosis in RA patients.
  • To determine if CEC levels correlate with carotid intima-media thickness (CIMT) and carotid plaque presence in RA.

Main Methods:

  • A cross-sectional study involving 178 RA patients and 223 controls.
  • Assessment of CEC via in vitro assay, alongside lipoprotein and lipid profiles.
  • Evaluation of carotid intima-media thickness (CIMT) and carotid plaque in RA patients using multivariable analysis.

Main Results:

  • No significant difference in mean CEC between RA patients and controls.
  • Lower CEC levels were observed in RA patients with low to moderate disease activity compared to those in remission.
  • Higher CEC was independently associated with a reduced risk of carotid plaque in RA patients, but not with CIMT.

Conclusions:

  • CEC is independently associated with the presence of carotid plaque in rheumatoid arthritis patients.
  • Disease activity in RA influences CEC levels.
  • CEC may serve as a potential biomarker for cardiovascular risk in RA.
Abstract

Keywords:
Cardiovascular diseaseCarotid intima-media thicknessCholesterol efflux capacityRheumatoid arthritis

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