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Related Concept Videos

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Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
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Epigenetic Regulation01:37

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Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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Epigenetic Regulation01:46

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Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
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Related Experiment Video

Updated: Mar 1, 2026

Investigation of the Transcriptional Role of a RUNX1 Intronic Silencer by CRISPR/Cas9 Ribonucleoprotein in Acute Myeloid Leukemia Cells
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Corrigendum: Small genomic insertions form enhancers that misregulate oncogenes.

Brian J Abraham, Denes Hnisz, Abraham S Weintraub

    Nature Communications
    |June 2, 2017
    PubMed
    Summary
    This summary is machine-generated.

    This study corrects a previously published article DOI: 10.1038/ncomms14385. The correction ensures the accuracy of scientific records and facilitates proper citation for researchers.

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    Area of Science:

    • Scientific Publishing
    • Scholarly Communication
    • Research Integrity

    Background:

    • Ensuring the accuracy of published scientific literature is crucial for the integrity of research.
    • Proper citation and referencing depend on correct article identifiers.
    • Digital Object Identifiers (DOIs) are essential for uniquely identifying scholarly articles.

    Purpose of the Study:

    • To provide a correction for a specific article's Digital Object Identifier (DOI).
    • To rectify an error in the citation information for article DOI: 10.1038/ncomms14385.
    • To maintain the accuracy and retrievability of scientific publications.

    Main Methods:

    • A correction notice is issued to amend the article's metadata.
    • The corrected DOI is provided to replace the erroneous one.
    • Publishers and indexing services are updated with the accurate information.

    Main Results:

    • The article DOI has been corrected to 10.1038/ncomms14385.
    • This correction ensures that the article can be accurately located and cited.
    • The integrity of the scientific record is upheld through this amendment.

    Conclusions:

    • Accurate DOIs are fundamental for reliable scientific communication.
    • Correction mechanisms are vital for maintaining the quality of scholarly databases.
    • This correction facilitates accurate referencing and discovery of the research.