Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Trouble with Trials: Systematic Review and Meta-Analysis of Randomized Controlled Trials Comparing Stereotactic Radiosurgery, Whole Brain Radiotherapy, and Observation for Resected Metastatic Brain Disease.

Cancers·2026
Same author

Biomarkers.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same author

Alzheimer's Imaging Consortium.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same author

Alzheimer's Imaging Consortium.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same author

Alzheimer's Imaging Consortium.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same author

Free-Breathing, 3D Cardiac Magnetic Resonance Elastography for Myocardial Stiffness Mapping.

Magnetic resonance in medicine·2025

Related Experiment Video

Updated: Mar 1, 2026

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
12:28

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Published on: June 3, 2020

18.4K

MR Elastography Demonstrates Unique Regional Brain Stiffness Patterns in Dementias.

Mona ElSheikh1, Arvin Arani1, Avital Perry2

  • 11 Department of Radiology, Mayo Clinic, 200 First St SW, Rochester, MN 55905.

AJR. American Journal of Roentgenology
|June 2, 2017
PubMed
Summary

Brain MR elastography (MRE) reveals distinct regional stiffness patterns for Alzheimer disease, frontotemporal dementia, and normal pressure hydrocephalus, aiding in dementia subtype differentiation.

Keywords:
MR elastographybrain stiffnessdementia

More Related Videos

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data
14:27

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data

Published on: June 26, 2013

16.4K
Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
09:33

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

29.4K

Related Experiment Videos

Last Updated: Mar 1, 2026

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
12:28

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Published on: June 3, 2020

18.4K
Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data
14:27

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data

Published on: June 26, 2013

16.4K
Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
09:33

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

29.4K

Area of Science:

  • Neuroimaging
  • Biomarker Discovery
  • Medical Physics

Background:

  • Dementia subtypes exhibit varied neuropathological changes.
  • Differentiating dementia subtypes is crucial for accurate diagnosis and treatment.
  • Magnetic Resonance Elastography (MRE) measures tissue viscoelasticity.

Purpose of the Study:

  • To investigate age-corrected brain MRE findings in Alzheimer disease (AD), dementia with Lewy bodies (DLB), frontotemporal dementia (FTD), and normal pressure hydrocephalus (NPH).
  • To assess the potential of MRE as a differentiating biomarker for dementia subtypes.

Main Methods:

  • 84 subjects underwent MRE, including 20 NPH, 8 AD, 5 DLB, 5 FTD, and 46 controls.
  • Brain stiffness was measured in eight regions using 60-Hz shear waves.
  • Stiffness values were age-corrected and statistically compared to controls.

Main Results:

  • AD and FTD showed decreased cerebral stiffness with frontal/temporal lobe softening.
  • AD additionally exhibited parietal lobe and sensorimotor region softening.
  • NPH demonstrated stiffening in parietal, occipital, and sensorimotor regions; DLB showed no significant changes.

Conclusions:

  • Quantitative MRE reveals unique regional brain stiffness patterns differentiating common dementia subtypes.
  • MRE shows potential as a non-invasive biomarker for distinguishing between dementia types.