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Author Spotlight: Advancements and Challenges in Hepatitis B Virus Detection
Published on: December 15, 2023
Adherence to Hepatitis B Antiviral Therapy: A Qualitative Study
Suzanne Polis1, Iryna Zablotska-Manos, Amany Zekry
1Suzanne Polis, MPH (research), BN, RN, is Senior Research Fellow (Nursing), Nursing Research & Practice Development Unit, The Sydney Children's Hospitals Network, Randwick New South Wales, Australia. Iryna Zablotska-Manos, PhD, BSc, is Senior Lecturer, The Kirby Institute, UNSW Australia, Wallace Wurth Building, Sydney NSW, Australia. Amany Zekry, PhD, MBBS, is Associate Professor and Hepatologist, St George Hospital, Department of Gastroenterology, Kogarah, New South Wales, Australia, and St George Hospital Clinical School of Medicine, UNSW, Australia. Lisa Maher, PhD, is Professor and Program Head and NHMRC Senior Research Fellow, Viral Hepatitis Epidemiology and Prevention Program Kirby Institute, UNSW Australia, Wallace Wurth Building, Sydney New South Wales, Australia.
Adherence to Hepatitis B virus (HBV) antiviral therapy is crucial for suppressing viral load. Key factors influencing adherence include patient-clinician communication, disease knowledge, routine, and fear of progression.
Area of Science:
- Hepatology
- Infectious Diseases
- Behavioral Science
Background:
- Hepatitis B virus (HBV) antiviral therapies aim to suppress viral load, reducing risks of liver disease and hepatocellular carcinoma.
- Maintaining viral suppression necessitates high adherence to antiviral treatments.
- Limited research exists on factors influencing adherence to HBV therapies.
Purpose of the Study:
- To explore factors influencing adherence to antiviral therapy in patients with Hepatitis B virus infection.
- To identify themes impacting patient adherence to HBV treatment regimens.
Main Methods:
- Qualitative study involving 29 participants undergoing HBV antiviral therapy.
- In-depth interviews conducted at three outpatient clinics in Sydney, Australia.
- Thematic analysis of transcribed interviews to identify adherence-related themes.
Main Results:
- 59% (n=17) of participants reported adherent behavior.
- Dominant themes influencing adherence included: routine, fear of disease progression, clinician-patient communication, treatment knowledge, and forgetfulness.
- An interplay of these themes emerged, highlighting their collective impact on adherence.
Conclusions:
- This is the first qualitative study to explore adherence to HBV antiviral therapy.
- Findings suggest that addressing patient knowledge, communication, routine, and fears can improve adherence.
- Results have implications for nursing and clinical practice in optimizing HBV treatment education and adherence monitoring.
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