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High prevalence of cognitive impairment after intracerebral hemorrhage

Mélanie Planton1,2, Laure Saint-Aubert3, Nicolas Raposo1,2

  • 1Department of Neurology, Toulouse University Hospital, Toulouse, France.

Plos One
|June 2, 2017
PubMed

Insights

Vascular cognitive disorders (VCDs) are common after intracerebral hemorrhage (ICH). Cognitive patterns in CAA-related and deep ICH survivors differ from Alzheimer's disease, with specific domain impairments observed.

Area of Science:

  • Neurology
  • Neuroscience
  • Cognitive Science

Background:

  • Cognitive impairment is frequent in intracerebral hemorrhage (ICH) survivors but understudied.
  • Vascular cognitive disorders (VCDs) are investigated in cerebral amyloid angiopathy (CAA)-related and deep ICH.
  • Comparison is made with Alzheimer's disease (AD) and healthy controls.

Purpose of the Study:

  • To investigate the frequency and patterns of VCDs in ICH survivors.
  • To compare cognitive profiles of CAA-related ICH, deep ICH, mild cognitive impairment due to AD (MCI-AD), and healthy controls.
  • To identify specific cognitive deficits in ICH survivors.

Main Methods:

  • Prospective recruitment of 20 CAA-related ICH, 20 deep ICH, 20 MCI-AD, and 17 healthy controls.
  • Comprehensive neuropsychological assessment and structural brain MRI.
  • Cognitive assessment at median 4 months post-ICH and >6 months post-complaint for MCI-AD; VASCOG criteria used for VCD prevalence.

Main Results:

  • 87.5% mild and 2.5% major VCDs observed in ICH patients.
  • CAA-related ICH patients showed mild VCDs; no cognitive difference between CAA-related and deep ICH.
  • Impaired naming, processing speed, executive function, memory, and attention in CAA group, distinct from MCI-AD.

Conclusions:

  • VCDs are frequent following ICH.
  • Cognitive patterns in deep and CAA-related ICH are similar but distinct from AD.
  • Specific cognitive domain impairments are identified in ICH survivors.
Abstract

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