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Insulin-Like Growth Factors and Metabolic Syndrome in Obese Children

Elena Inzaghi1, Barbara Baldini Ferroli1, Danilo Fintini1

  • 1Dipartimento Pediatrico Universitario Ospedaliero "Bambino Gesù" Children's Hospital-Tor Vergata University, Rome, Italy.

Hormone Research in Paediatrics
|June 2, 2017
PubMed

Insights

Insulin-like growth factors (IGFs) were not linked to metabolic syndrome in obese children. However, IGF-II was higher in obese youth and correlated with insulin sensitivity, suggesting a potential role.

Area of Science:

  • Pediatric Endocrinology
  • Metabolic Health
  • Growth Factors

Background:

  • Insulin-like growth factor (IGF)-I is linked to cardiometabolic risk in adults.
  • The metabolic role of IGF-II is less understood.
  • Obesity in children is a growing concern with potential metabolic complications.

Purpose of the Study:

  • To investigate Insulin-like growth factors (IGFs) in obese children.
  • To correlate IGF-I and IGF-II levels with metabolic syndrome (MetS) components.
  • To explore the relationship between IGFs and body composition in pediatric obesity.

Main Methods:

  • Retrospective analysis of 574 obese children (mean age 11.34 years).
  • Assessment of anthropometry, biochemical markers, and body composition.
  • Measurement of IGF-I in 300 and IGF-II in 77 obese children; categorization by MetS criteria.

Main Results:

  • IGF-I, IGF-II, and IGF-I/IGFBP-3 ratio did not correlate with the number of MetS criteria or body composition.
  • In younger children (<10 years), IGF-I correlated with high-density lipoprotein cholesterol.
  • IGF-II was elevated in obese children and associated with insulin sensitivity parameters.

Conclusions:

  • IGFs are not associated with MetS or body composition in obese children.
  • Further research is required to elucidate the connection between IGF-II and insulin sensitivity.
  • The findings suggest a complex interplay between IGFs, obesity, and metabolic health in pediatrics.
Abstract

Keywords:
Body compositionInsulin-like growth factorsMetabolic syndromeObesity

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