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Mechanistic Oral Absorption Modeling and Simulation for Formulation Development and Bioequivalence Evaluation: Report

X Zhang1, J Duan2, F Kesisoglou3

  • 1Office of Research and Standards, Office of Generic Drugs, US Food and Drug Administration, Silver Spring, Maryland, USA.

CPT: Pharmacometrics & Systems Pharmacology
|June 2, 2017
PubMed
Summary

Mechanistic oral absorption modeling uses physiologically based pharmacokinetic (PBPK) models to predict drug absorption. This approach integrates gastrointestinal processes for formulation development and bioequivalence evaluation.

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