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Intravenous nizatidine kinetics and acid suppression.
Clinical Pharmacology and Therapeutics
|February 1, 1985
Summary
Intravenous nizatidine effectively suppressed gastric acid secretion in two studies. Higher doses demonstrated prolonged suppression, with 100 mg showing effects comparable to cimetidine.
Area of Science:
- Pharmacology
- Gastroenterology
Background:
- Gastric acid suppression is crucial for managing acid-related disorders.
- Evaluating new intravenous agents for efficacy and safety is essential.
Purpose of the Study:
- To assess the efficacy of intravenous nizatidine in suppressing gastric acid secretion.
- To compare nizatidine's effects with placebo and cimetidine under different secretory stimuli.
Main Methods:
- Two single-blind studies were conducted using modified sham feeding and pentagastrin infusion to induce gastric secretion.
- Subjects received varying doses of intravenous nizatidine, placebo, or cimetidine.
- Gastric acid output, volume, and plasma nizatidine concentrations were measured.
Main Results:
- All tested doses of nizatidine reduced gastric acid secretion, primarily by decreasing volume.
- Nizatidine demonstrated a dose-response relationship, with 150 and 250 mg providing sustained suppression.
- 100 mg of nizatidine showed comparable acid suppression to 300 mg of cimetidine, with minor side effects.
Conclusions:
- Intravenous nizatidine is an effective gastric acid suppressant.
- Nizatidine exhibits a dose-dependent effect and favorable kinetics.
- Nizatidine represents a viable therapeutic option for conditions requiring gastric acid control.