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Advantages and Limitations of Current Biomarker Research: From Experimental Research to Clinical Application

Seung-Hyun Kim1, Christel Weiß2, Ursula Hoffmann1

  • 1First Department of Medicine, University Medical Centre Mannheim (UMM), Faculty of Medicine Mannheim, University of Heidelberg, Mannheim, Germany.

Current Pharmaceutical Biotechnology
|June 3, 2017
PubMed

Insights

Cardiovascular disease diagnosis benefits from multiple blood biomarkers, not just single markers. Novel approaches using proteins, metabolomics, and micro-RNAs offer improved clinical decision-making.

Area of Science:

  • Biomedical science
  • Biomarker discovery
  • Cardiovascular research

Background:

  • Biomarkers are crucial for cardiovascular disease (CVD) screening, diagnosis, and prognosis.
  • No single biomarker, including natriuretic peptides, fully captures the complexity of CVD.
  • Multi-marker strategies are increasingly important due to diverse CVD pathophysiologies.

Purpose of the Study:

  • To review the advantages and limitations of various blood-derived biomarkers for cardiovascular diseases.
  • To explore the utility of single and multi-marker approaches.
  • To focus on the clinical application of biomarkers in cardiovascular decision-making.

Main Methods:

  • Review of current literature on blood circulating biomarkers.
  • Analysis of protein, metabolomics, and transcriptional biomarkers.
  • Evaluation of single-marker versus multi-marker strategies.

Main Results:

  • Single biomarkers have limitations in comprehensively assessing CVD.
  • Multi-marker strategies offer a more nuanced understanding of CVD.
  • Novel biomarkers like micro-RNAs and omics data enhance CVD pathogenesis knowledge.

Conclusions:

  • Blood biomarkers, particularly multi-marker panels, are vital for cardiovascular disease management.
  • Proteins, metabolomics, and transcriptional markers provide complementary information.
  • Biomarker advancements support improved clinical decision-making in cardiology.
Abstract

Keywords:
Cardiovascular diseaseacute coronary syndromebiomarkerheart failuremetabolomemicro-RNAproteome

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