Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

2.1K
The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
2.1K
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

4.0K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
4.0K
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

532
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
532
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

496
Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
496
Carbohydrate Metabolism01:36

Carbohydrate Metabolism

14.6K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
14.6K
Peripheral Artery Disease IV: Nursing Management01:26

Peripheral Artery Disease IV: Nursing Management

499
 The nursing management of a patient with peripheral artery disease (PAD) begins with a thorough assessment of the patient’s health history and clinical manifestations.AssessmentHealth History: Evaluate the patient’s history of hypertension, hyperlipidemia, family history of cardiovascular issues, and lifestyle factors such as dietary patterns, smoking, and physical activity.Physical Examination:Assess the affected extremity for decreased or absent peripheral pulses,...
499

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

'Maybe you should have a bowl of ice cream': Inequities in patient-clinician interactions among individuals with chronic low back pain.

The journal of pain·2025
Same author

Feasibility of a UTE Stack-of-Spirals Sequence for T<sub>1ρ</sub> Mapping of Achilles Tendinopathy.

NMR in biomedicine·2025
Same author

Improving ChatGPT's Performance in Orthopedics: Opportunities Using the CRISPE Framework.

JOSPT methods·2025
Same author

Proximal and Distal Impairments in Runners With Achilles Tendinopathy Compared With Matched Controls.

Journal of strength and conditioning research·2025
Same author

GDF8 and activin A are the key negative regulators of muscle mass in postmenopausal females: a randomized phase I trial.

Nature communications·2025
Same author

Countermovement Jump Inefficiency Is Mostly Independent of Quadriceps Weakness in Athletes Returning to Sport After Anterior Cruciate Ligament Reconstruction.

Journal of strength and conditioning research·2025

Related Experiment Video

Updated: Mar 1, 2026

Author Spotlight: Integrating Tai Chi with Mindfulness Training to Achieve an Effective Mind-Body Exercise
05:06

Author Spotlight: Integrating Tai Chi with Mindfulness Training to Achieve an Effective Mind-Body Exercise

Published on: July 14, 2023

2.5K

Declining Skeletal Muscle Function in Diabetic Peripheral Neuropathy.

Prodromos Parasoglou1, Smita Rao2, Jill M Slade3

  • 1Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, New York; Center for Advanced Imaging Innovation and Research (CAI(2)R), Department of Radiology, New York University School of Medicine, New York, New York.

Clinical Therapeutics
|June 3, 2017
PubMed
Summary
This summary is machine-generated.

Diabetic peripheral neuropathy (DPN) affects skeletal muscle, leading to functional decline. Exercise offers a safe, cost-effective intervention to improve symptoms and cardiorespiratory function in DPN patients.

Keywords:
MRIdiabetic peripheral neuropathyexercise therapyskeletal muscle

More Related Videos

Assessing Mitochondrial Function in Sciatic Nerve by High-Resolution Respirometry
08:19

Assessing Mitochondrial Function in Sciatic Nerve by High-Resolution Respirometry

Published on: May 5, 2022

2.9K
Author Spotlight: Advancing Diabetes Research with Static Exercise Training in Mice
03:17

Author Spotlight: Advancing Diabetes Research with Static Exercise Training in Mice

Published on: March 29, 2024

1.1K

Related Experiment Videos

Last Updated: Mar 1, 2026

Author Spotlight: Integrating Tai Chi with Mindfulness Training to Achieve an Effective Mind-Body Exercise
05:06

Author Spotlight: Integrating Tai Chi with Mindfulness Training to Achieve an Effective Mind-Body Exercise

Published on: July 14, 2023

2.5K
Assessing Mitochondrial Function in Sciatic Nerve by High-Resolution Respirometry
08:19

Assessing Mitochondrial Function in Sciatic Nerve by High-Resolution Respirometry

Published on: May 5, 2022

2.9K
Author Spotlight: Advancing Diabetes Research with Static Exercise Training in Mice
03:17

Author Spotlight: Advancing Diabetes Research with Static Exercise Training in Mice

Published on: March 29, 2024

1.1K

Area of Science:

  • Neurology
  • Diabetology
  • Rehabilitation Medicine

Background:

  • Diabetic peripheral neuropathy (DPN) significantly impacts skeletal muscle function.
  • Current pharmacologic treatments for DPN are limited, necessitating exploration of alternative interventions.
  • Understanding DPN's effects on muscle is crucial for developing effective management strategies.

Purpose of the Study:

  • To review current knowledge on DPN's skeletal muscle effects.
  • To discuss the role of physical exercise in mitigating DPN-related limb issues.
  • To highlight the utility of magnetic resonance imaging (MRI) in understanding DPN mechanisms and guiding treatment development.

Main Methods:

  • Comprehensive review of DPN's impact on skeletal muscle in diabetic patients.
  • Update on recent clinical trials investigating exercise interventions for DPN.
  • Examination of emerging MRI techniques for mechanistic insights into DPN and clinical trial enhancement.

Main Results:

  • DPN-induced lower limb muscle impairments reduce function, increase fall risk, and affect balance.
  • Moderate-intensity exercise programs are safe for DPN patients, improving cardiorespiratory function and partially reversing symptoms.
  • MRI shows promise for providing mechanistic understanding and objectively measuring DPN pathology changes.

Conclusions:

  • Noninvasive exercise interventions are valuable for DPN due to safety, low cost, and synergy with pharmacologic treatments.
  • Enhanced mechanistic understanding of DPN will facilitate the design of more targeted and effective therapies.