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Measuring Deformability and Red Cell Heterogeneity in Blood by Ektacytometry
Published on: January 12, 2018
Erythrocyte deformability in peripheral occlusive arterial disease
Journal of Clinical Pathology
|February 1, 1985
Summary
Peripheral occlusive arterial disease (POAD) does not reduce erythrocyte deformability. Increased erythrocyte volume and serum gamma-glutamyl transpeptidase levels may influence blood flow measurements in POAD patients.
Area of Science:
- Biomedical Engineering
- Hematology
- Cardiovascular Research
Background:
- Peripheral occlusive arterial disease (POAD) is a condition affecting blood circulation.
- Previous studies suggested impaired erythrocyte deformability in POAD patients.
Purpose of the Study:
- To investigate erythrocyte deformability in patients with peripheral occlusive arterial disease (POAD).
- To identify factors contributing to altered blood flow measurements in POAD.
Main Methods:
- Rheological assessment of 32 POAD patients and 32 healthy controls.
- Erythrocyte deformability measured via filtration and viscometry.
- Erythrocyte ATP concentration and volume analyzed.
Main Results:
- No significant loss of erythrocyte deformability was found in POAD patients.
- POAD patients had a slight increase in mean erythrocyte volume.
- Elevated serum gamma-glutamyl transpeptidase correlated with filtration and viscosity measurements.
Conclusions:
- Intrinsic erythrocyte deformability is not compromised in POAD.
- Factors like increased erythrocyte volume, leucocytosis, or hyperfibrinogenaemia may explain previous findings of impaired blood filterability.
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