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Tigecycline treatment in an infant with extensively drug-resistant Acinetobacter baumannii bacteremia

Jiawei Zeng1, Lidan Zhang2, Min Gao3

  • 1Department of Pharmacy, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China.

International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases
|June 3, 2017
PubMed

Insights

Tigecycline successfully treated extensively drug-resistant Acinetobacter baumannii bacteremia in a pediatric liver transplant patient. Monitoring drug levels aided treatment, suggesting tigecycline for similar severe pediatric bacterial infections.

Area of Science:

  • Pediatric Infectious Diseases
  • Pharmacology and Therapeutics
  • Transplant Medicine

Background:

  • Extensively drug-resistant Acinetobacter baumannii (XDR-AB) poses a significant challenge in pediatric healthcare, particularly in immunocompromised patients.
  • Liver transplant recipients are vulnerable to severe bacterial infections due to immunosuppression.
  • Limited therapeutic options exist for XDR-AB infections in children.

Observation:

  • A 12-month-old liver transplant recipient presented with XDR-AB bacteremia.
  • Tigecycline was administered, with serum concentrations monitored to optimize efficacy and safety.
  • The patient showed a successful clinical response to tigecycline treatment.

Findings:

  • This case report details the successful use of tigecycline in a pediatric liver transplant patient with XDR-AB bacteremia.
  • Therapeutic drug monitoring of tigecycline was employed to guide treatment.
  • A literature review identified 11 prior pediatric cases of A. baumannii treated with tigecycline since 2011, supporting its use.

Implications:

  • Tigecycline is a viable treatment option for pediatric patients with XDR-AB infections.
  • Pharmacokinetic monitoring may enhance tigecycline's effectiveness and safety in pediatric populations.
  • Further research into tigecycline's role in treating severe pediatric bacterial infections is warranted.

Keywords:
TigecyclineXDR Acinetobacter baumanniibacteremiapediatric

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