New tactics for type 2 diabetes: regimens based on intermediate-acting insulin taken at bedtime

In type 2 diabetes mellitus, achieving normal fasting plasma glucose concentrations is probably more important than control of postprandial concentrations. It is suggested that, for some patients, treatment based on intermediate-acting insulin taken at bedtime will have more success than conventional regimens in lowering fasting, and thereby mean, plasma glucose concentrations, without causing hypoglycaemia.