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Associations between Interleukin-31 Gene Polymorphisms and Dilated Cardiomyopathy in a Chinese Population
Huizi Song1,2, Ying Peng1, Bin Zhou3
1Department of Cardiology, West China Hospital of Sichuan University, Chengdu 610041, China.
Disease Markers
|June 3, 2017
Summary
Interleukin-31 (IL-31) gene polymorphisms are linked to increased susceptibility to dilated cardiomyopathy (DCM). Specific IL-31 variants are associated with a worse prognosis in DCM patients, highlighting IL-31
Area of Science:
- Genetics
- Cardiology
- Immunology
Background:
- Dilated cardiomyopathy (DCM) is a complex heart condition with various contributing factors.
- Interleukin-31 (IL-31) is a cytokine implicated in inflammatory and immune responses.
- The specific role of IL-31 in the pathogenesis of DCM requires further investigation.
Purpose of the Study:
- To investigate the association between Interleukin-31 (IL-31) gene polymorphisms and susceptibility to dilated cardiomyopathy (DCM) in a Chinese Han population.
- To evaluate the impact of IL-31 genetic variations on the prognosis of DCM patients.
- To examine IL-31 mRNA expression levels in DCM patients.
Main Methods:
- Genotyping of two IL-31 single nucleotide polymorphisms (SNPs), rs4758680 (C/A) and rs7977932 (C/G), in 331 DCM patients and 493 controls.
- Analysis of IL-31 mRNA expression in white blood cells.
- Survival analysis using Kaplan-Meier curves and Cox regression models for 159 DCM patients.
Main Results:
- The C allele and CC genotype of IL-31 rs4758680 were significantly more frequent in DCM patients (P = 0.005, P = 0.001).
- Carriers of the A allele (CA/AA genotypes) at rs4758680 showed a protective effect against DCM susceptibility (P < 0.001, OR = 0.56).
- Increased IL-31 mRNA expression was observed in DCM patients compared to controls (P < 0.001).
- The CC genotype of rs4758680 was associated with a worse prognosis in DCM patients (P = 0.005), identified as an independent risk factor in survival analyses.
Conclusions:
- IL-31 gene polymorphisms, particularly rs4758680, are significantly associated with increased susceptibility to dilated cardiomyopathy.
- Specific IL-31 genotypes correlate with a poorer prognosis in DCM patients.
- IL-31 may play a crucial role in the development and progression of DCM.
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