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Denosumab Therapy for Giant Cell Tumor of Bone Pulmonary Metastasis
Ryan Carlisle Egbert1, Ryan Folsom2, Jeff Bell3
1Department of Orthopaedics, University of Texas Health San Antonio, MC 7774, 7703 Floyd Curl Drive, San Antonio, TX 78229-3900, USA.
Case:
A 68-year-old female was diagnosed with giant cell tumor of bone (GCTB) metastatic to her lungs. The patient was treated with IV denosumab for the course of 4.5 years for these metastases. The metastatic tumor burden decreased significantly after only 3 months of therapy. The size of the metastases has been stable for over 4 years.
Conclusion:
Denosumab therapy has promise in the treatment of GCTB, including pulmonary metastasis. However, the long-term role of denosumab for pulmonary metastases is yet to be determined.
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