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Updated: Mar 1, 2026

The In ovo CAM-assay as a Xenograft Model for Sarcoma
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Cardiac angiosarcoma: an unexpected diagnosis.

Milton Roberto Furst Crenitte1, Mariana Domingues Galvão2, Fabíola Del Carlo Bernardi3

  • 1Department of Internal Medicine - Hospital Universitário - Universidade de São Paulo, São Paulo/SP - Brazil.

Autopsy & Case Reports
|June 3, 2017
PubMed
Summary
This summary is machine-generated.

Cardiac angiosarcoma, a rare cancer, often presents with vague symptoms, delaying diagnosis. This case highlights an unexpected presentation of right atrial angiosarcoma in a middle-aged man.

Keywords:
Heart Neoplasms, Incidental FindingsHemangiosarcoma

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Area of Science:

  • Cardiology
  • Oncology
  • Radiology

Background:

  • Cardiac angiosarcoma is an exceptionally rare malignancy, with autopsy incidence between 0.001% and 0.03%.
  • Diagnosis is frequently delayed due to non-specific or absent symptoms, leading to unexpected findings.

Observation:

  • A middle-aged male presented with recent onset cough and dyspnea, initially undiagnosed.
  • Chest radiography revealed mediastinal enlargement, prompting hospitalization and further investigation.
  • Echocardiogram and CT scans identified a heterogeneous mass infiltrating the pericardium and right atrial wall, with pulmonary nodules.

Findings:

  • Biopsy of a pulmonary nodule confirmed angiosarcoma.
  • Combined clinical, radiological, and histological data led to the diagnosis of right atrial angiosarcoma.

Implications:

  • This case underscores the importance of considering rare cardiac tumors even with non-specific presentations.
  • Highlights the diagnostic challenges and unexpected patterns associated with cardiac tumors.
  • Emphasizes the role of advanced imaging and biopsy in diagnosing rare cardiac malignancies.