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MORIN MITIGATES OXIDATIVE STRESS, APOPTOSIS AND INFLAMMATION IN CEREBRAL ISCHEMIC RATS
Yanrong Chen1, Yanke Li1, Huali Xu1
1Department of Neurology, Binzhou city central hospital, Binzhou, Shandong 251700, China.
Background:
Morin is a flavanoid which exhibits potent antioxidant activity in various oxidative stress related diseases. The current study was attempted to scrutinize the preclinical bio-efficacy of morin on focal ischemia.
Methods:
The animal model of focal cerebral ischemic injury was done by midbrain carotid artery occlusion (MCAO) method, followed by Morin (30mg/kg) administration for seven days.
Results:
The outcome of the study showed that treatment with morin displayed positive effects in reducing the focal cerebral ischemia. This effect was evident with the improvements in neurological deficits, reduction in MDA content and elevation of antioxidant levels (SOD, GSH and Gpx). Furthermore, protein expression of Bax and caspase-3 were effectively down-regulated, whilst the expression of Bcl-2 was significantly elevated. On the other hand, the mRNA expression of proinflammatory cytokines was significantly reduced in focal cerebral ischemic rats upon morin intervention.
Conclusion:
Thus, the beneficial effects of morin on cerebral ischemia assault may result from the reduction of oxidative stress, inhibition of apoptosis and inflammation. The neuroprotective effects of morin supplement may serve as potent adjuvant in the amelioration of ischemic stroke.
Insights
Morin, a flavonoid with antioxidant properties, effectively reduced focal cerebral ischemia in rats. This neuroprotective effect was linked to decreased oxidative stress, apoptosis, and inflammation, suggesting its potential as an adjuvant therapy for ischemic stroke.
Area of Science:
- Biochemistry
- Neuroscience
- Pharmacology
Background:
- Morin is a flavonoid known for its potent antioxidant activity.
- Oxidative stress is implicated in various diseases, including focal ischemia.
- This study investigated the preclinical efficacy of morin in focal ischemia.
Purpose of the Study:
- To evaluate the neuroprotective effects of morin in a preclinical model of focal cerebral ischemia.
- To determine the mechanisms underlying morin's potential therapeutic benefits.
Main Methods:
- Focal cerebral ischemic injury was induced using the midbrain carotid artery occlusion (MCAO) method in an animal model.
- Morin was administered at a dose of 30mg/kg for seven consecutive days.
- Neurological deficits, oxidative stress markers (MDA, SOD, GSH, Gpx), apoptosis-related proteins (Bax, caspase-3, Bcl-2), and inflammatory cytokines were assessed.
Main Results:
- Morin treatment significantly improved neurological deficits in rats with focal cerebral ischemia.
- Biochemical analysis revealed reduced MDA levels and elevated antioxidant enzyme activities (SOD, GSH, Gpx) following morin administration.
- Morin downregulated pro-apoptotic proteins (Bax, caspase-3) and upregulated anti-apoptotic protein (Bcl-2), while also reducing pro-inflammatory cytokine mRNA expression.
Conclusions:
- Morin demonstrates beneficial effects in cerebral ischemia, likely through reducing oxidative stress, inhibiting apoptosis, and suppressing inflammation.
- The neuroprotective properties of morin suggest its potential as an effective adjuvant therapy for ischemic stroke.
