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3D Microfabricated Scaffolds and Microfluidic Devices for Ocular Surface Replacement: a Review
Elisabetta Prina1, Pritesh Mistry1, Laura E Sidney2
1Division of Regenerative Medicine and Cellular Therapies, School of Pharmacy, Centre for Biomolecular Sciences, University of Nottingham, Nottingham, UK.
Stem Cell Reviews and Reports
|June 3, 2017
Summary
Researchers are developing advanced 3D microfabricated corneal substitutes and models. These innovative technologies mimic native corneal microarchitecture and physiology for potential clinical and research applications.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Ophthalmology
Background:
- Growing interest in corneal substitutes for clinical use and in vitro models.
- Limitations of current methods in replicating native corneal complexity.
Purpose of the Study:
- To review innovative 3D microfabrication technologies for corneal substitute generation.
- To highlight advancements in recreating corneal microarchitecture and physiological conditions.
Main Methods:
- Review of recent literature on 3D microfabrication techniques.
- Analysis of hydrogel-based and microfluidic device developments.
- Focus on technologies enabling control over cell behavior and fluid dynamics.
Main Results:
- 3D microfabrication allows reconstruction of native corneal microarchitecture.
- Engineered constructs can control epithelial cell adhesion, migration, and differentiation.
- Inclusion of dynamic fluid flow mimics native corneal physiology.
Conclusions:
- 3D microfabricated hydrogels and microfluidic devices represent the latest innovations in corneal tissue engineering.
- These technologies hold promise for both clinical corneal repair and advanced in vitro corneal modeling.
