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Assessing Antiviral Countermeasures Using Mouse Models of Ebolavirus Infection
Andrea Kroeker1,2, Bryan D Griffin1,2, Xiangguo Qiu1,2
1National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada.
Methods in Molecular Biology (Clifton, N.J.)
|June 3, 2017
Abstract:
Mouse models of Ebola virus (EBOV) have demonstrated their utility as important tools for screening the efficacy of candidate therapeutics and vaccines. In this chapter we explain the various mouse models that utilize either wild-type or mouse-adapted EBOV variants.
Keywords:
Animal modelAntiviralDrug therapyEbola virusMonoclonal antibodiesMouseRecombinant vesicular stomatitis virus (rVSV)Vaccine
