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Testosterone effects on pain and brain activation patterns.

J C Choi1, Y-H Park2, S K Park3

  • 1Department of Anesthesiology and Pain Medicine, Intensive Care Unit, Brain Research Group, Yonsei University Wonju College of Medicine, Wonju, Gangwon-do, South Korea.

Acta Anaesthesiologica Scandinavica
|June 3, 2017
PubMed
Summary
This summary is machine-generated.

Lower testosterone levels in men are linked to increased pain perception and unpleasantness. This is associated with greater activation in brain regions related to pain unpleasantness, not pain intensity.

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Area of Science:

  • Neuroscience
  • Pain Research
  • Endocrinology

Background:

  • Pain perception and its subjective unpleasantness are influenced by various physiological factors.
  • Blood testosterone levels have been hypothesized to modulate pain processing and related emotional responses.
  • Specific brain regions, including the primary somatosensory cortex (S1) for pain intensity and the perigenual ACC (pACC) and orbitofrontal cortex (OFC) for unpleasantness, are implicated in pain perception.

Purpose of the Study:

  • To investigate the relationship between blood testosterone levels and subjective ratings of pain and pain-related unpleasantness.
  • To examine how testosterone levels affect the activation of brain regions associated with pain intensity (S1) and pain unpleasantness (pACC, OFC).

Main Methods:

  • Twenty-six healthy men were divided into high and low testosterone groups based on blood measurements.
  • Noxious thermal stimulation (50°C water bath) was applied to the middle finger of all participants.
  • Functional magnetic resonance imaging (fMRI) was used to measure brain activation patterns during stimulation.

Main Results:

  • The low testosterone group reported significantly higher ratings for pain, unpleasantness, anxiety, and fear compared to the high testosterone group.
  • Brain imaging revealed greater activation in the pACC and OFC in the low testosterone group during noxious stimulation.
  • Activation in the S1, a region associated with pain intensity, did not differ significantly between the groups.

Conclusions:

  • Lower testosterone levels are associated with heightened pain unpleasantness, driven by increased activity in the pACC and OFC, but not S1.
  • These findings highlight the role of testosterone in modulating the emotional and affective components of pain.
  • Clinical implications suggest considering testosterone levels in pain management strategies.