Enantioselective Iridium-Catalyzed Allylic Cyclizations
Michael A Schafroth1, Stephan M Rummelt1, David Sarlah1
1ETH Zürich , Vladimir-Prelog-Weg 3, 8093 Zürich, Switzerland.
Abstract:
A method for the enantioselective synthesis of carbo- and heterocyclic ring systems enabled through the combination of Lewis acid activation and iridium-catalyzed allylic substitution is described. The reaction proceeds with branched, allylic alcohols and carbon nucleophiles as well as heteronucleophiles to give a diverse set of ring systems in good yields and with high enantioselectivities. The utility of the method is highlighted by the asymmetric syntheses of erythrococcamides A and B.
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