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Published on: February 3, 2022
Mitochondrially derived peptides as novel regulators of metabolism
Su-Jeong Kim1, Jialin Xiao1, Junxiang Wan1
1Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Abstract:
Mitochondrially derived peptides represent a new class of circulating signalling molecules. Humanin, the first member of this class, has been shown to have several metabolic effects such as reducing weight gain and visceral fat and increasing glucose-stimulated insulin release. The discovery of several other new members, such as MOTS-c and SHLP1-6, has further added to this group. These new peptides have also been found to affect metabolism with MOTS-c potently decreasing weight gain in mice on a high-fat diet. This review covers the basic biology of this class of peptides and discusses the relevance to organismal metabolism.
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