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Muscle power in children, youth and young adults who acquired HIV perinatally

Η Μ Macdonald1, L Nettlefold, E J Maan

  • 1Department of Family Practice, University of British Columbia, Vancouver, Canada.

Journal of Musculoskeletal & Neuronal Interactions
|June 3, 2017
PubMed

Insights

Youth with perinatally acquired HIV show small deficits in muscle power compared to HIV-unexposed uninfected youth. These power deficits remained stable over two years, indicating a need for interventions to improve muscle function.

Area of Science:

  • Pediatric endocrinology
  • HIV/AIDS research
  • Sports medicine

Background:

  • Perinatal HIV infection can impact growth and development.
  • Muscle function is crucial for overall health and physical activity in youth.

Purpose of the Study:

  • To compare muscle power in youth with perinatal HIV infection versus HIV-unexposed uninfected (HUU) youth.
  • To assess changes in muscle power over a 24-month period.

Main Methods:

  • Assessed muscle power, force, efficiency, jump height, and velocity using a force platform in HIV+ youth and HUU controls.
  • Adjusted for height and muscle cross-sectional area (MCSA) in statistical analyses.
  • Longitudinal follow-up at 12 and 24 months.

Main Results:

  • HIV+ youth exhibited lower muscle power (Pmax/mass), force (Fmax/BW), and velocity (Vmax) compared to HUU controls at baseline.
  • Muscle power deficits were associated with immunosuppression but not after adjusting for height and MCSA.
  • Muscle power outcomes remained stable over the 24-month study period.

Conclusions:

  • Children and youth with perinatally acquired HIV demonstrate subtle deficits in muscle power.
  • Muscle power trajectories are stable over two years in this population.
  • Further research is required to develop strategies for enhancing dynamic muscle function in youth with HIV.
Abstract

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