Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Infertility in Females01:28

Infertility in Females

4.9K
Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
Endometriosis, a condition characterized by abnormal growth of...
4.9K
Infertility in Males01:23

Infertility in Males

620
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
620
In Vitro Fertilization01:24

In Vitro Fertilization

1.1K
In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
1.1K
Cancer Survival Analysis01:21

Cancer Survival Analysis

805
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
805
Tumor Progression02:07

Tumor Progression

7.6K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
7.6K
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

3.8K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Living with Xeroderma Pigmentosum: a qualitative study of the psychosocial challenges experienced by families of children with a rare skin disorder.

Orphanet journal of rare diseases·2026
Same author

Factors associated with health-related quality of life in survivors of childhood-onset and adult-onset cancer compared to controls.

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer·2026
Same author

'They Need to Hear You Say It': Healthcare Professionals' Perspectives on Barriers and Enablers to End-of-Life Discussions With Adolescents and Young Adults With Cancer.

Pediatric blood & cancer·2026
Same author

Reproductive outcomes after fertility preservation using tamoxifen or letrozole in women with breast cancer: a long-term follow-up.

F&S reports·2026
Same author

Integrated Germline and Somatic Molecular Profiling to Detect Cancer Predisposition Has a High Clinical Impact in Poor-Prognosis Pediatric Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research·2026
Same author

Haematological cancer in pregnancy in New South Wales, Australia: A population-based retrospective cohort study.

Cancer epidemiology·2026
Same journal

Reduced Circulating Polyamines in Polyendocrine Metabolic Ovarian Syndrome (PMOS) Patients and the Impact of Putrescine on Ovarian Function and Fertility in a Murine PMOS Model.

Biology of reproduction·2026
Same journal

DEVELOPMENTAL PROGRAMMING IN DOGS.

Biology of reproduction·2026
Same journal

Meiosis-Specific Cohesin in Mammalian Germ Cells.

Biology of reproduction·2026
Same journal

The Research of Lactylation in the Field of Reproduction.

Biology of reproduction·2026
Same journal

Mitochondria as Integrative Regulators of Ferroptosis in the Female Reproductive System.

Biology of reproduction·2026
Same journal

Retraction and replacement of: Navigation of Nanos germ cell specification factor to germ granules-posttranscriptional regulation hubs-across species.

Biology of reproduction·2026
See all related articles

Related Experiment Video

Updated: Mar 1, 2026

Collection of Human Follicular Fluid, Follicle Somatic Cells, and Immature Oocytes from Individuals Undergoing In Vitro Fertilization
06:40

Collection of Human Follicular Fluid, Follicle Somatic Cells, and Immature Oocytes from Individuals Undergoing In Vitro Fertilization

Published on: October 24, 2025

1.0K

Global oncofertility index-data gap slows progress.

Saskia F de Roo1, Alexandra S Rashedi2, Catharina C M Beerendonk3

  • 1Department of Obstetrics and Gynecology, Radboud University Medical Center, Nijmegen, The Netherlands; Northwestern University, Chicago, Illinois, USA.

Biology of Reproduction
|June 3, 2017
PubMed
Summary
This summary is machine-generated.

Developing a global oncofertility index (OFI) to assess reproductive loss in cancer survivors is currently unachievable due to data limitations. This prevents meaningful comparisons and evaluation of oncofertility care worldwide.

Keywords:
fertility, adolescent young adultoncofertilityoncology

More Related Videos

Z-Scores for Assessing Ovarian Reserve in Young Patients Undergoing Fertility Preservation
05:42

Z-Scores for Assessing Ovarian Reserve in Young Patients Undergoing Fertility Preservation

Published on: October 25, 2024

1.6K
Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives
08:46

Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives

Published on: September 16, 2021

6.8K

Related Experiment Videos

Last Updated: Mar 1, 2026

Collection of Human Follicular Fluid, Follicle Somatic Cells, and Immature Oocytes from Individuals Undergoing In Vitro Fertilization
06:40

Collection of Human Follicular Fluid, Follicle Somatic Cells, and Immature Oocytes from Individuals Undergoing In Vitro Fertilization

Published on: October 24, 2025

1.0K
Z-Scores for Assessing Ovarian Reserve in Young Patients Undergoing Fertility Preservation
05:42

Z-Scores for Assessing Ovarian Reserve in Young Patients Undergoing Fertility Preservation

Published on: October 25, 2024

1.6K
Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives
08:46

Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives

Published on: September 16, 2021

6.8K

Area of Science:

  • Oncology
  • Reproductive Medicine
  • Public Health

Background:

  • Increasing numbers of pediatric and young adult cancer survivors globally.
  • Growing concern regarding cancer-related infertility and reproductive hormone loss in survivors.
  • Need for standardized metrics to evaluate oncofertility care and outcomes.

Purpose of the Study:

  • To estimate reproductive loss in oncofertility-practicing countries.
  • To develop a global oncofertility index (OFI) for national comparisons.
  • To assess the urgency and current management of oncofertility issues.

Main Methods:

  • Exploratory analysis of existing global data on cancer survivorship and reproductive health.
  • Conceptual framework development for a potential global oncofertility index.
  • Identification of data gaps and limitations for index calculation.

Main Results:

  • The development of a meaningful global oncofertility index is currently unachievable.
  • Significant data deficiencies exist regarding country-specific reproductive loss metrics.
  • Lack of standardized data prevents comprehensive assessment and comparison of oncofertility care.

Conclusions:

  • The absence of necessary data precludes the creation of a global oncofertility index.
  • Without such a metric, assessing oncofertility care progress and learning from international best practices is hindered.
  • Further efforts are needed to collect standardized data to address reproductive health concerns in cancer survivors.