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Related Experiment Videos

Alprazolam-induced mania: two clinical cases.

G W Arana, C Pearlman, R I Shader

    The American Journal of Psychiatry
    |March 1, 1985
    PubMed
    Summary

    Alprazolam treatment may trigger manic episodes in patients with underlying bipolar disorder. These episodes responded to lithium, suggesting a potential complication of alprazolam use.

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    Area of Science:

    • Psychiatry
    • Pharmacology

    Background:

    • Bipolar disorder is a mood disorder characterized by shifts in mood, energy, and activity levels.
    • Alprazolam is a benzodiazepine commonly prescribed for anxiety and panic disorders.

    Observation:

    • Two patients with a history suggestive of bipolar disorder developed manic episodes after treatment with alprazolam.
    • The induced manic episodes were responsive to lithium treatment.

    Findings:

    • Alprazolam administration may precipitate manic episodes in susceptible individuals, particularly those with undiagnosed or subclinical bipolar disorder.
    • The findings highlight a potential drug-induced mania associated with alprazolam use.

    Implications:

    • Clinicians should exercise caution when prescribing alprazolam to patients with a history suggestive of bipolar disorder.
    • Screening for bipolar disorder may be warranted in patients initiating alprazolam therapy.
    • This association underscores the importance of considering medication side effects in the differential diagnosis of mood disturbances.

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