Related Experiment Video

Updated: Mar 1, 2026

An Approach to Study Shape-Dependent Transcriptomics at a Single Cell Level
06:02

An Approach to Study Shape-Dependent Transcriptomics at a Single Cell Level

Published on: November 2, 2020

6.3K

[Aging of the myocardium and dilated cardiomyopathy: morphological and molecular aspects]

I B Antonov1, K L Kozlov1, N S Linkova1,2

  • 1Saint-Petersburg Institute of Bioregulation and Gerontology, Saint-Petersburg, 197110, Russian Federation; linkova@gerontology.ru.

Advances in Gerontology = Uspekhi Gerontologii
|June 3, 2017
PubMed

Insights

Myocardium aging involves fibrosis and cellular changes, with reduced Sirt1 expression potentially predicting dilated cardiomyopathy (DC). DC is marked by heart chamber stretching, inflammation, and altered matrix metalloproteinase levels.

Area of Science:

  • Cardiovascular Biology
  • Aging Research
  • Cardiomyopathy Studies

Background:

  • Myocardium aging involves significant structural and functional alterations.
  • Dilated cardiomyopathy (DC) is characterized by ventricular dilation and impaired systolic function.
  • Understanding aging's impact on the heart is crucial for managing cardiovascular diseases.

Purpose of the Study:

  • To review the multifaceted aspects of myocardium aging in both normal aging and dilated cardiomyopathy (DC).
  • To explore the molecular and cellular changes associated with cardiac aging.
  • To identify potential biomarkers and mechanisms linking aging to DC development.

Main Methods:

  • Review of existing literature on myocardial aging and dilated cardiomyopathy.
  • Analysis of cellular and molecular changes, including fibrosis, protein expression, and inflammatory markers.
  • Comparison of aging processes in normal hearts versus those with DC.

Main Results:

  • Normal aging leads to myocardial fibrosis (collagen type 1, amyloid), cardiomyocyte loss (men), and reduced Sirt1 expression.
  • Decreased Sirt1 expression correlates with accelerated aging and may predict DC.
  • DC involves heart chamber stretching, inflammation (ICAM-1, MMPs, TIMP-1), and altered matrix metalloproteinase activity.

Conclusions:

  • Myocardium aging is a complex process with distinct cellular and molecular hallmarks.
  • Reduced Sirt1 expression is a significant indicator of accelerated cardiac aging and a potential predictor for DC.
  • DC is characterized by inflammation and specific changes in extracellular matrix remodeling markers.

Keywords:
ICAM-1dilated cardiomyopathymatrix metalloproteinasesmyocardium agingsirtuin-1

More Related Videos

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix10:21

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix

Published on: June 14, 2016

10.7K
A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo05:14

A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo

Published on: May 16, 2020

5.5K

Related Concept Videos

Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
673
Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
702
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
574
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
1.1K
Myocarditis I: Introduction01:21

Myocarditis I: Introduction

Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
498
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
551