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Related Concept Videos

Epigenetic Regulation01:46

Epigenetic Regulation

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Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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Epigenetic Regulation01:37

Epigenetic Regulation

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Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
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Genomics02:02

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Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
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Genomic Imprinting and Inheritance02:30

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Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
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Histone Modification02:32

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Histone Modification02:32

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The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
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Updated: Mar 1, 2026

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Looking Back: Epigenomics

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    Summary
    This summary is machine-generated.

    This review explores how epigenomic changes drive cell reprogramming and lineage specification. It highlights influential studies that have advanced our understanding in these key areas of developmental biology.

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    Area of Science:

    • Developmental Biology
    • Epigenetics
    • Cellular Reprogramming

    Background:

    • The field of epigenomics has significantly advanced our understanding of cellular processes.
    • Cellular reprogramming and lineage specification are critical areas of biological research.
    • A decade of research has yielded substantial progress in understanding epigenomic modifications.

    Purpose of the Study:

    • To review the impact of influential epigenomic studies.
    • To understand how these studies have shaped research in reprogramming and lineage specification.
    • To celebrate a decade of advancements in the field.

    Main Methods:

    • Surveying authors who cited key epigenomics papers.
    • Analyzing the influence of selected publications on subsequent research.
    • Synthesizing expert perspectives on the field's trajectory.

    Main Results:

    • Identified seminal epigenomic studies that have driven progress.
    • Documented the significant influence of these studies on researchers' work.
    • Highlighted the collective impact on the broader scientific community.

    Conclusions:

    • Epigenomic research has profoundly impacted cell reprogramming and lineage specification.
    • Key publications continue to guide and inspire future scientific endeavors.
    • The field is poised for continued innovation, building on a strong foundational decade.