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Updated: Mar 1, 2026

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

Updates in Postmastectomy Radiation.

Jean L Wright¹, Arti Parekh¹

¹Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Suite 1440, 401 North Broadway, Baltimore, MD 21231, USA.

Surgical Oncology Clinics of North America

|June 4, 2017

Summary

This summary is machine-generated.

Postmastectomy radiation therapy (PMRT) use is debated in some breast cancer cases. This review examines current data and evolving challenges to guide clinical decisions on PMRT.

Keywords:

Clinical risk factors Locoregional failure Mastectomy Postmastectomy Radiation

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Area of Science:

Oncology
Radiation Oncology
Breast Cancer Management

Background:

Postmastectomy radiation therapy (PMRT) is standard in specific high-risk breast cancer scenarios.
Evolving breast cancer treatments, such as sentinel lymph node biopsy and neoadjuvant chemotherapy, are altering PMRT indications.
Controversies remain regarding the optimal use of PMRT in certain patient groups.

Purpose of the Study:

To review existing data supporting current postmastectomy radiation therapy recommendations.
To explore areas of controversy in PMRT application.
To analyze studies guiding clinicians in complex PMRT scenarios.

Main Methods:

Literature review of clinical trials and guidelines.
Analysis of data from studies addressing PMRT in the context of modern breast cancer management.
Synthesis of evidence to address clinical controversies.

Main Results:

Current evidence supports PMRT in specific high-risk situations.
Shifting treatment paradigms create new challenges for PMRT decision-making.
Data are emerging to address controversies in select patient populations.

Conclusions:

PMRT remains a critical component of breast cancer treatment for select patients.
Clinical judgment and careful review of evidence are essential for optimizing PMRT use.
Ongoing research is needed to refine PMRT guidelines amidst changing treatment landscapes.