Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Clinical Applications of Epidermal Stem Cells

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...

Renewal of Skin Epidermal Stem Cells

Renewal of Skin Epidermal Stem Cells

The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Outcomes and Challenges of Flap Reconstruction for Pressure Injuries in Clinically Complex Patients.

Journal of clinical medicine·2026

Same author

Short-Term Functional Trajectories After Surgery in Older Adults: National Patterns of Loss and Recovery in 436,471 Patients.

Annals of surgery open : perspectives of surgical history, education, and clinical approaches·2026

Same author

Artificial Intelligence-Based Risk Prediction Models for Complications After Tongue Cancer Surgery.

JAMA otolaryngology-- head & neck surgery·2026

Same author

The Utility and Applicability of the Modified 5-Item Frailty Index in Cosmetic Surgery.

Aesthetic plastic surgery·2026

Same author

Low protein, high risk: hypoalbuminemia predicts adverse outcomes after mastectomy in 37,848 breast cancer patients.

Breast cancer (Tokyo, Japan)·2026

Same author

Dementia and postoperative outcomes in older adults: national estimates and mechanistic pathways from a US cohort study.

Age and ageing·2026

Same journal

Lower-Extremity Reconstruction: Principles, Progress, and Perspectives.

Clinics in plastic surgery·2026

Same journal

Pediatric.

Clinics in plastic surgery·2026

Same journal

Lower Extremity Reconstruction in Acute Burns.

Clinics in plastic surgery·2026

Same journal

Chronic Lower Extremity Wounds: Updates on Lower Extremity Reconstruction in Clinics in Plastic Surgery.

Clinics in plastic surgery·2026

Same journal

Updates in Lower Extremity Reconstruction: Post Sarcoma.

Clinics in plastic surgery·2026

Same journal

Fillet Flaps for Lower Extremity Salvage.

Clinics in plastic surgery·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Mar 1, 2026

A Full Skin Defect Model to Evaluate Vascularization of Biomaterials In Vivo

A Full Skin Defect Model to Evaluate Vascularization of Biomaterials In Vivo

Published on: August 28, 2014

Skin Substitutes and Bioscaffolds: Temporary and Permanent Coverage.

Anthony G Haddad¹, Giorgio Giatsidis², Dennis P Orgill²

¹Department of Surgery, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA.

Clinics in Plastic Surgery

|June 4, 2017

Summary

This summary is machine-generated.

Skin substitutes and bioscaffolds offer advanced wound coverage for burns, aiding healing and preventing infection. However, no single product is currently considered the optimal standard for all patients.

Keywords:

Allografts Bioscaffolds Dermal templates Skin substitutes Xenografts

More Related Videos

Fabrication of a Bioactive, PCL-based "Self-fitting" Shape Memory Polymer Scaffold

Fabrication of a Bioactive, PCL-based "Self-fitting" Shape Memory Polymer Scaffold

Published on: October 23, 2015

Generation of Self-assembled Vascularized Human Skin Equivalents

Generation of Self-assembled Vascularized Human Skin Equivalents

Published on: February 12, 2021

Related Experiment Videos

Last Updated: Mar 1, 2026

A Full Skin Defect Model to Evaluate Vascularization of Biomaterials In Vivo

A Full Skin Defect Model to Evaluate Vascularization of Biomaterials In Vivo

Published on: August 28, 2014

Fabrication of a Bioactive, PCL-based "Self-fitting" Shape Memory Polymer Scaffold

Fabrication of a Bioactive, PCL-based "Self-fitting" Shape Memory Polymer Scaffold

Published on: October 23, 2015

Generation of Self-assembled Vascularized Human Skin Equivalents

Generation of Self-assembled Vascularized Human Skin Equivalents

Published on: February 12, 2021

Area of Science:

Regenerative Medicine
Biomaterials Science
Wound Healing Research

Background:

Skin substitutes and bioscaffolds are crucial for burn wound management, providing temporary or permanent coverage.
These materials aim to restore skin function and aesthetics while preventing infection and maintaining a moist healing environment.
Limitations of autografts and allografts (cost, availability) drive the use of xenografts and engineered skin substitutes.

Purpose of the Study:

To review the current landscape of skin substitutes and bioscaffolds in surgical wound treatment.
To highlight their role in managing burn wounds and improving patient outcomes.
To assess the current state of development and identify the lack of a definitive gold standard.

Main Methods:

Literature review of advancements in skin substitutes and bioscaffolds for wound coverage.
Analysis of the functional and aesthetic benefits of these materials.
Evaluation of their role in infection prevention and wound environment maintenance.

Main Results:

Skin substitutes and bioscaffolds are increasingly utilized for burn wound coverage.
These products offer benefits in restoring skin qualities and promoting a conducive healing environment.
Despite ongoing innovation, a universally accepted gold standard product has not yet emerged.

Conclusions:

The field of engineered skin substitutes and bioscaffolds shows significant progress in wound healing.
These advanced materials play a vital role in managing complex wounds, particularly burns.
Further research and development are needed to establish a superior, standardized treatment option.