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Updated: Mar 1, 2026

Author Spotlight: A Multi-Depth Porcine Model for Comprehensive Study of Burn Injuries and Healing Processes
Published on: February 23, 2024
Management of the Chronic Burn Wound
Stephen Tyler Elkins-Williams1, William A Marston2, Charles Scott Hultman1
1Division of Plastic and Reconstructive Surgery, Department of Surgery, University of North Carolina Medical Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Abstract:
This article reviews the current evidence in using hyperbaric oxygen therapy (HBOT) in burn wounds. There is also separate consideration of diabetic foot burns and a protocol for use of HBOT in a specific case. The challenges of using HBOT in an acute burn care setting are reviewed. Next the pathophysiology of Marjolin ulcers is reviewed. The current thinking in diagnosis, treatment, and prevention of Marjolin ulcers is discussed. Finally, a background in using topical growth factors (tGF) is provided, followed by a summary of the current evidence of tGF in burn wounds.
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