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Effects of Donor Breastmilk Feeding on Growth and Early Neurodevelopmental Outcomes in Preterm Infants: An
Laura S Madore1, Samudragupta Bora2, Carmina Erdei3
1Department of Pediatric Newborn Medicine, Tufts Medical Center, Boston, Massachusetts; Department of Pediatric Newborn Medicine, Baystate Medical Center, Springfield, Massachusetts.
Insights
Donor breastmilk (DBM) use in preterm infants may lead to slower initial weight gain and potential cognitive delays compared to mother's own milk (MOM) or preterm formula (PF). Further research is needed on optimal DBM use.
Area of Science:
- Neonatal Nutrition
- Developmental Pediatrics
Background:
- Donor breastmilk (DBM) is increasingly used for preterm infants when mother's own milk (MOM) is unavailable.
- Preterm infants have unique nutritional and developmental needs.
Purpose of the Study:
- To evaluate the impact of a predominantly DBM diet on growth and neurodevelopment in preterm infants.
- To compare outcomes of DBM-fed infants with those fed MOM or preterm formula (PF).
Main Methods:
- Observational cohort study in a level 3 NICU.
- Compared preterm infants receiving >50% DBM with age/weight-matched infants fed MOM or >50% PF.
- Assessed in-hospital weight gain and neurodevelopment (Bayley III scale) at 1 and 2 years corrected age.
Main Results:
- DBM infants showed slower initial birthweight regain compared to MOM or PF groups (P=0.05).
- Cognitive scores at 1 and 2 years were significantly lower in the DBM group compared to non-DBM groups (P=0.005 and P=0.03, respectively).
Conclusions:
- Predominantly DBM supplementation in preterm infants may be associated with compromised early growth and potential cognitive delays.
- Highlights the need for further research into optimal DBM utilization and continued support for breastfeeding to provide MOM.
Purpose:
Donor breastmilk (DBM) has gained popularity as an alternative to formula when mother's own milk (MOM) is unavailable. The objective of this study was to evaluate the effects of a predominantly DBM diet on growth and subsequent neurodevelopment in preterm infants at a level 3 neonatal intensive care unit (NICU).
Methods:
This single-center, observational cohort study compared data from preterm infants supplemented with predominantly (>50%) DBM to those from age- and weight-matched infants fed only MOM or supplemented with predominantly (>50%) preterm formula (PF). The primary outcome was in-hospital weight gain, and the secondary outcome was neurodevelopment, as assessed by the Bayley III scale at 1 and 2 years' corrected age. Exclusion criteria were major congenital defects, death prior to discharge from the NICU, or supplementation volumes of <50% over the first month of life. We compared the outcomes among the 3 feeding groups with the χ2 test, ANOVA, and ANCOVA, with post hoc pairwise comparisons after adjustment for the following confounders: bronchopulmonary dysplasia, multiple births, and social work involvement.
Findings:
In the entire cohort, the mean gestational age was 27.1 weeks and the mean birthweight was 914 g. The DBM (n = 27) and PF (n = 25) groups were similar with regard to socioeconomic characteristics. DBM infants regained birthweight more slowly over the first month of life compared with infants fed MOM (n = 29) or PF (mean [SD], 17.9 [5.7], 22.0 [6.8], and 20.3 [5.7] g/kg/d, respectively; P = 0.05); however, this growth difference was attenuated at later time points. In a fully adjusted model, the DBM group scored significantly lower in cognition at both 1 year (P = 0.005) and 2 years (P = 0.03) of age compared with the infants fed non-DBM diets.
Implications:
The findings from this study suggest that in this NICU, preterm infants supplemented with predominantly DBM had compromised early in-hospital weight gain and, possibly, early cognitive delays compared with infants fed only MOM or infants supplemented with predominantly PF. These findings reinforce the need for further research on the optimal use of DBM in the preterm population and a continued need for promoting breastfeeding efforts to supply MOM.
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