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Using Mouse Oocytes to Assess Human Gene Function During Meiosis I
Published on: April 10, 2018
Genetic basis of eugonadal and hypogonadal female reproductive disorders
Tatiana Trofimova1, Daria Lizneva2, Larisa Suturina3
1Department of Reproductive Health Protection, Scientific Center of Family Health and Human Reproduction, 16, Timiryazeva Street, 664003, Irkutsk, Russian Federation.
Abstract:
This review discusses the current state of our understanding regarding the genetic basis of the most important reproductive disorders in women. For clarity, these disorders have been divided into eugonadal and hypogonadal types. Hypogonadal disorders have been further subdivided according to serum gonadotropin levels. Our review focuses on historical and recent data regarding the genetics of the hypothalamic-pituitary-gonadal axis dysfunction, as well as the development and etiology of eugonadal disorders including leiomyomata, endometriosis, spontaneous ovarian hyperstimulation syndrome, polycystic ovarian syndrome, mullerian aplasia, and steroid hormone resistance syndromes. We discuss the known genes most commonly involved in hypergonadotropic hypogonadism (Turner syndrome and premature ovarian failure) and hypogonadotrophic hypogonadism (Kallmann syndrome and normosmic types). In addition, we summarize the current clinical testing approaches and their utility in practical application.
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