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Updated: Mar 1, 2026

A Protocol for Safe Lithiation Reactions Using Organolithium Reagents
Published on: November 12, 2016
Do not treat the numbers: lithium toxicity
Peter Foulser1, Yasmin Abbasi1, Anand Mathilakath1
1Department of Psychiatry, Surrey and Borders Partnership NHS Foundation Trust, Leatherhead, Surrey, UK.
Abstract:
We describe the case of a 62-year-old man with a history of bipolar disorder, previously stable on lithium for over 20 years, who presented with a manic relapse and signs of lithium toxicity in the form of a coarse tremor. Serum lithium levels were in the normal range, and the patient had stage 3 chronic kidney disease. He was admitted for treatment under Section 2 of the Mental Health Act, and after stopping lithium was started on olanzapine. Signs of lithium toxicity improved after withdrawal of lithium. This case highlights the need to treat normal serum lithium levels with caution in patients showing signs of clinical lithium toxicity.
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