Related Experiment Video

Updated: Mar 1, 2026

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
09:02

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion

Published on: February 2, 2021

5.0K

[Non-dialytic treatment of acute kidney injury]

Julien Demiselle1, Nicolas Lerolle1

  • 1Département de réanimation médicale et médecine hyperbare, CHU d'Angers, 4, rue Larrey, 49933 Angers, France.

Nephrologie & Therapeutique
|June 5, 2017
PubMed

Insights

Acute kidney injury (AKI) is common in intensive care units, increasing mortality and chronic kidney disease risk. Despite numerous interventions, none have proven effective in large trials, necessitating further research.

Area of Science:

  • Nephrology
  • Critical Care Medicine

Background:

  • Acute kidney injury (AKI) is a prevalent complication in intensive care units (ICUs).
  • AKI is linked to increased mortality and progression to chronic renal failure.
  • Even minor elevations in serum creatinine indicate poor outcomes.

Purpose of the Study:

  • To review recent interventions for improving acute kidney injury in ICU patients.
  • To summarize various therapeutic strategies evaluated for AKI management.

Main Methods:

  • Literature review of recent publications on AKI interventions in ICUs.
  • Categorization of interventions including hemodynamic, pharmacological, and regenerative approaches.

Main Results:

  • Numerous interventions have been investigated, including hemodynamic support, anti-inflammatory agents, and remote ischemic conditioning.
  • No single intervention has demonstrated consistent efficacy in large-scale randomized controlled trials.
  • Specific AKI drugs and renal recovery stimulation are emerging areas.

Conclusions:

  • Despite extensive research, effective treatments for AKI in ICUs remain elusive.
  • A comprehensive approach addressing inflammation, hemostasis, and renal recovery is needed.
  • Further robust clinical trials are essential to identify successful AKI interventions.
Keywords:
Acute kidney injuryInsuffisance rénale aiguëIntensive care unitRéanimationTraitementTreatment

More Related Videos

Technical Refinement of a Bilateral Renal Ischemia-Reperfusion Mouse Model for Acute Kidney Injury Research03:13

Technical Refinement of a Bilateral Renal Ischemia-Reperfusion Mouse Model for Acute Kidney Injury Research

Published on: November 3, 2023

3.1K
Nephrotoxin Microinjection in Zebrafish to Model Acute Kidney Injury07:58

Nephrotoxin Microinjection in Zebrafish to Model Acute Kidney Injury

Published on: July 17, 2016

9.3K

Related Concept Videos

Acute Kidney Injury V: Interprofessional Care01:20

Acute Kidney Injury V: Interprofessional Care

Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
407
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
391
Acute Kidney Injury I: Introduction01:22

Acute Kidney Injury I: Introduction

Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
928
Acute Kidney Injury VI: Nursing Management01:22

Acute Kidney Injury VI: Nursing Management

Acute Kidney Injury (AKI) results in an inability to maintain fluid, electrolyte, and acid-base balance. Effective nursing management is critical in improving patient outcomes and includes comprehensive patient assessment and targeted interventions.Comprehensive Patient AssessmentA detailed history collection is essential, focusing on any recent infections, nephrotoxic medication use, or chronic conditions such as hypertension and diabetes that may contribute to AKI. During the physical...
577
Dialysis01:27

Dialysis

Renal failure occurs when the kidneys lose their ability to filter waste products from the blood effectively. It can be classified into two types: acute renal failure (ARF) and chronic renal failure (CRF).
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
1.7K
Dialysis01:15

Dialysis

Dialysis is a diffusion-based purification process that separates analyte molecules from a complex matrix. This is accomplished by allowing molecules in the solution to pass through a semipermeable membrane into a liquid on the other side. The membrane is usually made of cellulose acetate or cellulose nitrate, and the second liquid must be miscible with the solution. Ions (e.g., chloride or sodium) or organic molecules (e.g., glucose) can pass through the membrane pores, which generally have...
2.0K