Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

5.9K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
5.9K
Allergic Reactions02:06

Allergic Reactions

32.7K
Overview
32.7K
Hypersensitivities01:30

Hypersensitivities

7.9K
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
7.9K
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

64
Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial...
64
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

1.5K
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
1.5K
Hypersensitivity Reactions: Delayed Hypersensitivity Reactions01:29

Hypersensitivity Reactions: Delayed Hypersensitivity Reactions

87
Delayed-Type Hypersensitivity (DTH), or Type IV hypersensitivity, is a cell-mediated immune response. It occurs when T cells, rather than antibodies, mediate a reaction to specific antigens. It is characterized by a delayed onset (1-2 days) and involves the recruitment of macrophages to the inflammation site.The initiation of a DTH response begins with the sensitization of T cells. During this phase, which lasts at least 1-2 weeks, antigen-specific T cells are activated, clonally expanded, and...
87

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Defining the Potential for Disease Modification in Atopic Dermatitis.

American journal of clinical dermatology·2026
Same author

Highlights from the 2025 Symposium of the Collegium Internationale Allergologicum.

The Journal of allergy and clinical immunology·2026
Same author

Sustained on/off-treatment disease control with abrocitinib for moderate-to-severe atopic dermatitis.

The Journal of dermatological treatment·2026
Same author

From Sprinters to Marathoners: Rethinking Therapeutic Speed and Disease Modification in Atopic Dermatitis.

Allergy·2026
Same author

Letter to the editor submitted in response to 'Are potential remittive properties of OX-40 inhibitors something to be excited about?'

The Journal of dermatological treatment·2026
Same author

International Eczema Council Definitions of Low Disease Activity and Remission in Atopic Dermatitis: A Consensus Statement.

JAMA dermatology·2026

Related Experiment Video

Updated: Mar 1, 2026

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach
09:32

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach

Published on: September 26, 2019

7.7K

How to Define Atopic Dermatitis?

Thomas Bieber1

  • 1Department of Dermatology and Allergy, Christine Kühne-Center for Allergy Research and Education, University Medical Center, Sigmund-Freud-Street 25, Bonn 53127, Germany.

Dermatologic Clinics
|June 5, 2017
PubMed
Summary
This summary is machine-generated.

Atopic dermatitis (AD) diagnosis needs reevaluation beyond immunoglobulin E levels. New biomarkers and adapted criteria are crucial for precise, global treatment of this common skin disorder.

Keywords:
Atopic dermatitisDefinitionEczemaImmunoglobuline EPrecision medicine

More Related Videos

Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment
06:47

Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment

Published on: September 27, 2017

10.2K
A Mouse Ear Model for Allergic Contact Dermatitis Evaluation
08:02

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation

Published on: March 24, 2023

5.1K

Related Experiment Videos

Last Updated: Mar 1, 2026

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach
09:32

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach

Published on: September 26, 2019

7.7K
Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment
06:47

Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment

Published on: September 27, 2017

10.2K
A Mouse Ear Model for Allergic Contact Dermatitis Evaluation
08:02

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation

Published on: March 24, 2023

5.1K

Area of Science:

  • Dermatology
  • Immunology
  • Genetics

Background:

  • Atopic dermatitis (AD) is a prevalent skin condition with ongoing debate regarding its definition and diagnostic criteria.
  • Current diagnostic approaches, often relying on immunoglobulin E (IgE) levels, present a binary view that may not capture the full spectrum of AD.
  • The diverse clinical presentations of AD suggest complex underlying genetic and pathophysiological mechanisms.

Purpose of the Study:

  • To highlight the limitations of current atopic dermatitis diagnostic criteria.
  • To emphasize the need for reconsidering diagnostic approaches, including adaptation for diverse ethnic populations.
  • To underscore the importance of biomarker discovery for advancing precision medicine in AD.

Main Methods:

  • Literature review and synthesis of current research on atopic dermatitis.
  • Analysis of existing diagnostic criteria and their limitations.
  • Discussion of the role of genetics, pathophysiology, and ethnic variations in AD.

Main Results:

  • The current definition and diagnostic criteria for AD are debated.
  • The clinical phenotype of AD is highly variable, reflecting complex disease mechanisms.
  • Existing diagnostic methods may not adequately represent the disease spectrum across different populations.

Conclusions:

  • Diagnostic criteria for atopic dermatitis require reevaluation and adaptation for various ethnic groups.
  • Biomarker discovery is essential to support clinical diagnosis and enable a precision medicine approach.
  • A global, refined approach to AD diagnosis and treatment is urgently needed.