Atherosclerosis and Cancer; A Resemblance with Far-reaching Implications

Area of Science:

• Pathology
• Oncology
• Cardiovascular Medicine

Background:

• Atherosclerosis and cancer are leading global causes of mortality.
• Both are multifactorial diseases sharing common molecular pathways and ethiological processes.
• Shared factors include genetic alterations, inflammation, uncontrolled cell proliferation, and oxidative stress.

Purpose of the Study:

• To provide evidence and discuss approaches for identifying molecular ties between atherosclerosis and cancer.
• To highlight the resemblance of atherosclerosis to neoplastic processes.
• To explore novel therapeutic strategies based on these shared mechanisms.

Main Methods:

• Comparative analysis of molecular pathways in atherosclerosis and cancer.
• Review of ethiological and mechanistic processes from early to advanced stages.
• Discussion of external effectors initiating atherogenesis and neoplastic progression.

Main Results:

• Identified shared processes such as deregulation of cell cycle, altered transcription factors and adhesion molecules.
• Highlighted similarities in angiogenesis control and chronic inflammation molecularly.
• Emphasized the parallels between atherogenesis and neoplastic progression.

Conclusions:

• Atherosclerosis exhibits significant resemblances to neoplastic development.
• Further research into shared molecular mechanisms can reveal novel therapeutic targets.
• Recognizing atherosclerosis as a neoplastic-like process may lead to innovative treatments.