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Protein kinase D signaling in cancer: A friend or foe?

Adhiraj Roy1, Jing Ye2, Fan Deng3

  • 1Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, 200 Lothrop Street, Pittsburgh, PA 15261, USA.

Biochimica Et Biophysica Acta. Reviews on Cancer
|June 5, 2017
PubMed

Insights

Protein kinase D (PKD) plays complex roles in cancer. This review examines PKD

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Oncology

Background:

  • Protein kinase D (PKD) is a serine/threonine kinase family within the Ca++/Calmodulin-dependent kinase superfamily.
  • PKD signaling is activated by diverse stimuli and regulates key cellular processes like proliferation, survival, and migration.

Purpose of the Study:

  • To review the structural-functional properties, activation, and signaling of PKD in human cancer.
  • To comprehensively analyze the dual role of PKD as a tumor promoter or suppressor across various cancer types.

Main Methods:

  • Literature review of studies on PKD expression, function, and regulation in cancer.
  • Analysis of reported discrepancies in PKD's role in malignant transformation.

Main Results:

  • PKD exhibits cell- and tissue-specific expression and functions in cancer-associated processes.
  • PKD has documented tumor-promoting and tumor-suppressive roles, leading to conflicting findings.

Conclusions:

  • The precise roles of PKD in cancer progression remain elusive and require further investigation.
  • Understanding the differential effects of PKD is crucial for its therapeutic targeting in cancer.
Keywords:
CancerFunctionPKDRegulationSignaling mechanismsStructure

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